Complexity and application of pedigree analysis programme GTree

D. Ogino, S. Mori, Masato Nose, H. Sawada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A novel recombinant congenic mouse strain, McRA1lpr/lpr, which was established by the intercrosses between MRL/Mp/-lpr/lpr and C3H/HeJ-lpr/lpr strains throughout more than F50 generations by means of selection based on swelling of ankle joints, manifested severe arthritis, followed by ankylosis, pathologically resembling rheumatoid arthritis in humans. To clarify the genetic mechanisms on the development of arthritis in this strain, we newly prepared "GTree" for analyzing the pedigree of pathological phenotypes of arthritis, splenomegaly and lymphadenopathy based on the collected data from over 700 McRA1-lpr/lpr mice collected and arranged by Shiro MORI. The data themselves are now dealt with by a PostgreSQL Linux server administered by Hideki SAWADA. We explain the algorithm of the program and its complexity, and show the pathological peculiarity of spleens and axillary lymph nodes which appear only in the group of RA mice.

Original languageEnglish
Title of host publicationProceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages333-335
Number of pages3
ISBN (Electronic)076951653X, 9780769516530
DOIs
Publication statusPublished - 2002 Jan 1
Event1st International IEEE Computer Society Bioinformatics Conference, CSB 2002 - Stanford, United States
Duration: 2002 Aug 142002 Aug 16

Publication series

NameProceedings - IEEE Computer Society Bioinformatics Conference, CSB 2002

Other

Other1st International IEEE Computer Society Bioinformatics Conference, CSB 2002
CountryUnited States
CityStanford
Period02/8/1402/8/16

Keywords

  • GTree
  • McRA1 mouse
  • Pedigree analysis
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Artificial Intelligence
  • Software
  • Biomedical Engineering
  • Health Informatics

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