TY - JOUR
T1 - Complexed prostate-specific antigen and its volume indexes in the detection of prostate cancer
AU - Maeda, Hiroshi
AU - Arai, Yoichi
AU - Aoki, Yoshitaka
AU - Okubo, Kazutoshi
AU - Okada, Takashi
AU - Maekawa, Shinya
N1 - Funding Information:
This study was supported in part by a Grant-in-Aid for the Study on the Treatment of Non-palpable Prostate Cancer from the Japanese Ministry of Health and Welfare, and in part by a Grant-in-Aid from the Sagawa Foundation for the promotion of cancer research.
PY - 1999/8
Y1 - 1999/8
N2 - Objectives. To evaluate complexed prostate-specific antigen (cPSA), cPSA density (cPSAD), and cPSA adjusted for the transition zone volume (cPSA-TZ) in comparison with the free-to-total PSA ratio (F/T PSA) and free-to- complexed PSA ratio (F/C PSA) as a means of diagnosing prostate cancer. Methods. Transition zone volume was determined in 137 of 142 men who underwent systematic sextant biopsies and had total PSA (tPSA) values between 4.1 and 10.0 ng/mL. cPSAD and cPSA-TZ were calculated by dividing the cPSA value by the whole prostate volume and the transition zone volume, respectively. Results. Of the 137 men, 23 (16.8%) had prostate cancer. cPSA predicted the biopsy outcome better than tPSA, F/T PSA, or F/C PSA, although the difference was not significant. A cutoff value of 4.1 ng/mL for cPSA provided a specificity of 42% and a sensitivity of 87%. A combination of cPSA and F/C PSA maintained a sensitivity of 83% and gave an increased specificity of 54%. In a subgroup of 65 patients with smaller prostate volumes (less than 45 mL), the diagnostic value of cPSA-TZ was remarkably increased. A cutoff value of 0.31 for cPSA-TZ provided a sensitivity of 93% and a high specificity of 72%. Conclusions. cPSA was more specific than tPSA and F/T PSA. As a component of F/C PSA, free PSA could provide additional value to cPSA. cPSA-TZ and cPSAD could be better indicators for prostate cancer than cPSA.
AB - Objectives. To evaluate complexed prostate-specific antigen (cPSA), cPSA density (cPSAD), and cPSA adjusted for the transition zone volume (cPSA-TZ) in comparison with the free-to-total PSA ratio (F/T PSA) and free-to- complexed PSA ratio (F/C PSA) as a means of diagnosing prostate cancer. Methods. Transition zone volume was determined in 137 of 142 men who underwent systematic sextant biopsies and had total PSA (tPSA) values between 4.1 and 10.0 ng/mL. cPSAD and cPSA-TZ were calculated by dividing the cPSA value by the whole prostate volume and the transition zone volume, respectively. Results. Of the 137 men, 23 (16.8%) had prostate cancer. cPSA predicted the biopsy outcome better than tPSA, F/T PSA, or F/C PSA, although the difference was not significant. A cutoff value of 4.1 ng/mL for cPSA provided a specificity of 42% and a sensitivity of 87%. A combination of cPSA and F/C PSA maintained a sensitivity of 83% and gave an increased specificity of 54%. In a subgroup of 65 patients with smaller prostate volumes (less than 45 mL), the diagnostic value of cPSA-TZ was remarkably increased. A cutoff value of 0.31 for cPSA-TZ provided a sensitivity of 93% and a high specificity of 72%. Conclusions. cPSA was more specific than tPSA and F/T PSA. As a component of F/C PSA, free PSA could provide additional value to cPSA. cPSA-TZ and cPSAD could be better indicators for prostate cancer than cPSA.
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U2 - 10.1016/S0090-4295(99)00149-1
DO - 10.1016/S0090-4295(99)00149-1
M3 - Article
C2 - 10443715
AN - SCOPUS:0032801173
SN - 0090-4295
VL - 54
SP - 225
EP - 228
JO - Urology
JF - Urology
IS - 2
ER -
