Complete separation of ternary mixture of amino acids using continuous rotating annular chromatography with partial recycling of effluent

Takuya Fukumura, Vinay M. Bhandari, Akio Kitakawa, Toshikuni Yonemoto

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Continuous rotating annular chromatography with partial recycling of the effluent (CRAC-PRE) was used for the separation of a ternary mixture of amino acids. A mathematical model describing the separation process was constructed to find the optimized operating conditions. The effectiveness of the CRAC-PRE for the separation of a ternary mixture was experimentally and theoretically elucidated by comparison to conventional CRAC. A recycling loop which gives reasonable separation was successfully arranged on the basis of the numerical simulation result. A combination of CRAC-PRE with the step elution method was applied to the complete separation of a ternary mixture of amino acids.

Original languageEnglish
Pages (from-to)778-784
Number of pages7
JournalJOURNAL of CHEMICAL ENGINEERING of JAPAN
Volume33
Issue number5
DOIs
Publication statusPublished - 2000 Jan 1

Keywords

  • Amino acid
  • Complete separation
  • Partial recycling
  • Step elution
  • Ternary mixture

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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