Complete Remission in Systemic Skin Interdigitating Dendritic Cell Sarcoma after ABVD Chemotherapy

Chieko Kyogoku, Masanori Seki, Shinichi Ogawa, Kana Miyamoto, Yufu Ito, Naoki Kurita, Yasuhisa Yokoyama, Mamiko Sakata-Yanagimoto, Naoshi Obara, Yuichi Hasegawa, Fumiyoshi Fujishima, Ryo Ichinohasama, Shigeo Nakamura, Shigeru Chiba

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Interdigitating dendritic cell sarcoma (IDCS) is a rare and aggressive neoplasm that is thought to arise from dendritic cells. This disease usually involves the lymph nodes and, rarely, extra-nodal sites. We report a 62-year-old man presenting skin nodules in the head, body, and extremities, as well as bone marrow involvement. Morphologic analysis of a biopsied specimen from the skin lesion was consistent with IDCS. Immunohistochemical staining demonstrated that the tumor cells were positive for IDCS-associated antigens such as CD4, CD45, CD68 (KP-1), and S-100 protein. Complete remission was achieved by treatment with 6 cycles of ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine) chemotherapy. Although the optimal treatment of IDSC remains unknown, the experience in the current case supports the notion that ABVD chemotherapy may be effective for IDCS, and further extends this idea to rare patients presenting multiple skin lesions.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalJournal of clinical and experimental hematopathology : JCEH
Volume55
Issue number1
DOIs
Publication statusPublished - 2015
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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