Complement-Mediated Killing of Borrelia garinii —Bactericidal Activity of Wild Deer Serum

Emiko Isogai; Yuri Kamewaka; Hiroshi Isogai; Koichi Kimura; Nobuhiro Fujii’; Takeshi Nishikawa

Complement-Mediated Killing of Borrelia garinii —Bactericidal Activity of Wild Deer Serum

Emiko Isogai, Yuri Kamewaka, Hiroshi Isogai, Koichi Kimura, Nobuhiro Fujii’, Takeshi Nishikawa

AGR - Bioscience and Biotechnology for Future Bioindustries

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The susceptibility of Borrelia garinii to fresh wild deer sera was determined by incubating strain SIKA2 at 10% serum concentration for 1 hr at 37 C in an in vitro bactericidal assay. Each serum showed bactericidal effects at various levels. The effect was dependent on the concentration of antibody to the spirochetes. Complement was essential in the bactericidal assay because the inactivated deer serum showed greatly decreased activity. Our results suggest that B. garinii is sensitive to deer serum, in the presence of antibody and the bactericidal effect is important for preventing Lyme disease in wild sika deer.

Original language	English
Pages (from-to)	753-756
Number of pages	4
Journal	MICROBIOLOGY and IMMUNOLOGY
Volume	38
Issue number	9
Publication status	Published - 1994 Jan 1

Keywords

Antibody
Borrelia garinii
Complement-mediated killing
Wild deer serum

ASJC Scopus subject areas

Microbiology
Immunology
Virology

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abstract = "The susceptibility of Borrelia garinii to fresh wild deer sera was determined by incubating strain SIKA2 at 10% serum concentration for 1 hr at 37 C in an in vitro bactericidal assay. Each serum showed bactericidal effects at various levels. The effect was dependent on the concentration of antibody to the spirochetes. Complement was essential in the bactericidal assay because the inactivated deer serum showed greatly decreased activity. Our results suggest that B. garinii is sensitive to deer serum, in the presence of antibody and the bactericidal effect is important for preventing Lyme disease in wild sika deer.",

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AU - Isogai, Emiko

AU - Kamewaka, Yuri

AU - Isogai, Hiroshi

AU - Kimura, Koichi

AU - Fujii’, Nobuhiro

AU - Nishikawa, Takeshi

PY - 1994/1/1

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AB - The susceptibility of Borrelia garinii to fresh wild deer sera was determined by incubating strain SIKA2 at 10% serum concentration for 1 hr at 37 C in an in vitro bactericidal assay. Each serum showed bactericidal effects at various levels. The effect was dependent on the concentration of antibody to the spirochetes. Complement was essential in the bactericidal assay because the inactivated deer serum showed greatly decreased activity. Our results suggest that B. garinii is sensitive to deer serum, in the presence of antibody and the bactericidal effect is important for preventing Lyme disease in wild sika deer.

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KW - Borrelia garinii

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KW - Wild deer serum

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Complement-Mediated Killing of Borrelia garinii —Bactericidal Activity of Wild Deer Serum

Abstract

Keywords

ASJC Scopus subject areas

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