Complement-Mediated Killing of Borrelia garinii —Bactericidal Activity of Wild Deer Serum

Emiko Isogai, Yuri Kamewaka, Hiroshi Isogai, Koichi Kimura, Nobuhiro Fujii’, Takeshi Nishikawa

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The susceptibility of Borrelia garinii to fresh wild deer sera was determined by incubating strain SIKA2 at 10% serum concentration for 1 hr at 37 C in an in vitro bactericidal assay. Each serum showed bactericidal effects at various levels. The effect was dependent on the concentration of antibody to the spirochetes. Complement was essential in the bactericidal assay because the inactivated deer serum showed greatly decreased activity. Our results suggest that B. garinii is sensitive to deer serum, in the presence of antibody and the bactericidal effect is important for preventing Lyme disease in wild sika deer.

Original languageEnglish
Pages (from-to)753-756
Number of pages4
JournalMICROBIOLOGY and IMMUNOLOGY
Volume38
Issue number9
Publication statusPublished - 1994 Jan 1

Keywords

  • Antibody
  • Borrelia garinii
  • Complement-mediated killing
  • Wild deer serum

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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