Complement-induced thrombus formation on the surface of poly(N-vinylpyrpolidone)-grafted polyethylene

H. Fukumura, K. Hayashi, S. Yoshikawa, M. Miya, N. Yamamoto, I. Yamashita

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


The role of complement activation in thrombogenesis was investigated on the surface of hydrophilic monomer-graft copolymerized polyethylene (PE) tubes. N-vinylpyrrolidone (NVP)-grafted tubes activated in an in vitro complement system of canine serum; but no activation occurred in 2-hydroxyethyl methacrylate (HEMA)-grafted tubes. The relative patent time for NVP-grafted tubes implanted in canine peripheral veins was shorter than that for HEMA-grafted tubes and adhesion of numerous leucocytes was observed on the luminal surfaces of the NVP-grafted tubes. Decomplementation by prior administration of cobra venom factor elongated the relative patent time for NVP-grafted tubes only and also inhibited the adhesion of leucocytes onto them. These results suggest that the complement activation participates in thrombus formation on the polymer surfaces in canine veins.

Original languageEnglish
Pages (from-to)74-76
Number of pages3
Issue number1
Publication statusPublished - 1987 Jan


  • 2-hydroxyethyl methacrylate
  • N-vinylpyrrolidone
  • Polymers
  • biocompatibility
  • complement
  • graft-copolymerization
  • thrombogenesis

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials


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