Abstract
The role of complement activation in thrombogenesis was investigated on the surface of hydrophilic monomer-graft copolymerized polyethylene (PE) tubes. N-vinylpyrrolidone (NVP)-grafted tubes activated in an in vitro complement system of canine serum; but no activation occurred in 2-hydroxyethyl methacrylate (HEMA)-grafted tubes. The relative patent time for NVP-grafted tubes implanted in canine peripheral veins was shorter than that for HEMA-grafted tubes and adhesion of numerous leucocytes was observed on the luminal surfaces of the NVP-grafted tubes. Decomplementation by prior administration of cobra venom factor elongated the relative patent time for NVP-grafted tubes only and also inhibited the adhesion of leucocytes onto them. These results suggest that the complement activation participates in thrombus formation on the polymer surfaces in canine veins.
| Original language | English |
|---|---|
| Pages (from-to) | 74-76 |
| Number of pages | 3 |
| Journal | Biomaterials |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1987 Jan |
Keywords
- 2-hydroxyethyl methacrylate
- N-vinylpyrrolidone
- Polymers
- biocompatibility
- complement
- graft-copolymerization
- thrombogenesis
ASJC Scopus subject areas
- Bioengineering
- Ceramics and Composites
- Biophysics
- Biomaterials
- Mechanics of Materials