Competitive study of monoclonal antibodies against the HIV-1 Gp41 core structure

Osamu Usami, Peng Xiao, Hong Ling, Toshio Hattori

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Monoclonal antibodies (MAbs) 50.69, 98.6, and T26 bind specifically to the core structure of the human immunodeficiency virus type 1 (HIV-1) envelope transmembrane glycoprotein (gp41). To clarify the specificity of the anti-core structure MAbs, we performed competitive assays using the MAbs to the H9 human T cell line infected with the IIIB strain of HIV-1 (H9/IIIB). Bound MAb 50.69 inhibited MAb 98.6 binding unidirectionally. The reason for the unidirectional cross competition between MAbs 50.69 and 98.6 is not clear, but these results help to define the antigenic structure of gp41 on the surface of infected cells.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalMICROBIOLOGY and IMMUNOLOGY
Volume50
Issue number2
DOIs
Publication statusPublished - 2006

Keywords

  • 50.69 antibody
  • 98.6 antibody
  • Gp41
  • HIV-1

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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