Compartment analysis of 123I-Iomazenil brain SPECT in patients with moyamoya disease

Tomohiro Kaneta, Tetsuro Yamazaki, Shin Maruoka, Yoetsu Abe, Shoki Takahashi, Shogo Yamada

Research output: Contribution to journalArticlepeer-review


We investigated 11 patients with moyamoya disease about 123I-Iomazenil kinetics in the brain using three-compartment, two-parameter model. The transition rate constant (K1) from the blood to the brain and the binding potential (BP) of the benzodiazepine to the receptors were calculated for every ROI (right and left side of cerebellum, frontal lobe, parietal lobe, occipital lobe and temporal lobe; 10 ROIs a case). The K1 value correlated with BP value significantly, but not so closely (r=0.639). And there is no significant difference in BP value among low-K1 group (mean (of K1) -S.D.≦K1≦ mean) and high-K1 group (mean≤K1 ≦mean+S.D.). This means that CBF and BP do not correlate closely in the average Moyamoya disease patients. And we showed a case with IMP/IMZ discrepancy. The nerve cell in the hypoperfused area which has almost normal BP value is ischemic but viable. IMZ-SPECT presents an important information about the viability of the hypoperfused area in Moyamoya disease patients' brain.

Original languageEnglish
Pages (from-to)1011-1012
Number of pages2
Issue number9
Publication statusPublished - 1999 Dec 1


  • Benzodiazepine receptor
  • Iomazenil
  • Moyamoya disease
  • Quantitative analysis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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