Comparisons of accumulation and excretion of iminosugars among mulberry-feeding specialist Bombyx larvae and non-specialist larvae

Masatoshi Hori, Shigeto Komatsubara, Kiyotaka Nakagawa, Oki Higuchi, Shinji Onose, Teruo Miyazawa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Silkworms (Bombyx mori L.) accumulate 1-deoxynojirimycin (DNJ), a mulberry iminosugar, by feeding on mulberry leaves. DNJ is a potent α-glucosidase inhibitor that helps prevent diabetes. However, iminosugars are toxic to many insects. In this study, we analyzed the concentrations of three major mulberry iminosugars—DNJ, 2-O-α-d-galactopyranosyl-DNJ (GAL-DNJ), and fagomine—in the larvae of mulberry-feeding insect species (two mulberry specialists and six non-specialists), to clarify the differences in accumulation, metabolism, and excretion of iminosugars between specialists and non-specialists. DNJ and fagomine concentrations in the two Bombyx larvae were much higher than those in the other larvae. GAL-DNJ concentrations were low in all species. DNJ and fagomine concentrations in the excrements of Agrotis segetum (Denis and Schiffermüller) and Sarcopolia illoba (Butler) larvae were lower than in those of the other larvae. Further, iminosugar concentrations in the hemolymph of B. mori, B. mandarina Moore, and S. illoba larvae were analyzed. DNJ and fagomine concentrations in the hemolymph of the two Bombyx larvae were much higher than in that of S. illoba. DNJ concentrations in the whole bodies of the two Bombyx larvae decreased as they developed. Similarly, DNJ, and fagomine concentrations in the hemolymph of B. mori larvae decreased with growth.

Original languageEnglish
Pages (from-to)571-578
Number of pages8
JournalApplied Entomology and Zoology
Volume49
Issue number4
DOIs
Publication statusPublished - 2014 Nov

Keywords

  • 1-Deoxynojirimycin
  • Accumulation
  • Bombyx mandarina
  • Bombyx mori
  • Iminosugar
  • Mulberry

ASJC Scopus subject areas

  • Insect Science

Fingerprint Dive into the research topics of 'Comparisons of accumulation and excretion of iminosugars among mulberry-feeding specialist Bombyx larvae and non-specialist larvae'. Together they form a unique fingerprint.

Cite this