TY - JOUR
T1 - Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease
AU - Waragai, Masaaki
AU - Okamura, Nobuyuki
AU - Furukawa, Katsutoshi
AU - Tashiro, Manabu
AU - Furumoto, Shozo
AU - Funaki, Yoshihito
AU - Kato, Motohisa
AU - Iwata, Ren
AU - Yanai, Kazuhiko
AU - Kudo, Yukitsuka
AU - Arai, Hiroyuki
PY - 2009/10/15
Y1 - 2009/10/15
N2 - Two techniques employed for the early diagnosis of dementia are the imaging of amyloid-β protein using positron emission tomography (PET) and voxel-based morphometry analysis of MRI (VBM-MRI). The purpose of this study was to evaluate the clinical utility of amyloid PET and VBM-MRI for the early diagnosis and tracking of the severity of Alzheimer's disease (AD). The neuritic plaque burden and gray matter losses were evaluated using [11C]BF-227-PET and VBM-MRI in 12 healthy controls, 13 subjects with mild cognitive impairment (MCI), including 6 who converted to AD and 7 who did not convert, and 15 AD patients. The AD patients and the MCI converters exhibited a neocortical retention of BF-227 and parahippocampal gray matter loss shown by VBM-MRI. The MCI converters were more clearly distinguished from the MCI non-converters in BF-227-PET than VBM-MRI. The combined sample of the MCI converters and AD patients showed a significant correlation of MMSE scores with the global gray matter loss, but not with the BF-227 retention. These findings suggest that amyloid PET using [11C]BF-227 is better suited for the prediction of conversion from MCI to AD, while VBM-MRI appears to be better suited for tracking the severity of dementia.
AB - Two techniques employed for the early diagnosis of dementia are the imaging of amyloid-β protein using positron emission tomography (PET) and voxel-based morphometry analysis of MRI (VBM-MRI). The purpose of this study was to evaluate the clinical utility of amyloid PET and VBM-MRI for the early diagnosis and tracking of the severity of Alzheimer's disease (AD). The neuritic plaque burden and gray matter losses were evaluated using [11C]BF-227-PET and VBM-MRI in 12 healthy controls, 13 subjects with mild cognitive impairment (MCI), including 6 who converted to AD and 7 who did not convert, and 15 AD patients. The AD patients and the MCI converters exhibited a neocortical retention of BF-227 and parahippocampal gray matter loss shown by VBM-MRI. The MCI converters were more clearly distinguished from the MCI non-converters in BF-227-PET than VBM-MRI. The combined sample of the MCI converters and AD patients showed a significant correlation of MMSE scores with the global gray matter loss, but not with the BF-227 retention. These findings suggest that amyloid PET using [11C]BF-227 is better suited for the prediction of conversion from MCI to AD, while VBM-MRI appears to be better suited for tracking the severity of dementia.
KW - Alzheimer's disease
KW - Amyloid
KW - BF-227
KW - Early diagnosis
KW - Magnetic resonance imaging
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=69549089908&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69549089908&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2009.06.005
DO - 10.1016/j.jns.2009.06.005
M3 - Article
C2 - 19552926
AN - SCOPUS:69549089908
VL - 285
SP - 100
EP - 108
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
IS - 1-2
ER -