Comparison of Ventilatory Response between Dead Space and CO2 Breathing in Humans

Ryoko Maruyama; Hidenori Masuyama; Yukio Tanaka; Yoshitake Nishibayashi; Yoshiyuki Honda

doi:10.2170/jjphysiol.38.321

Comparison of Ventilatory Response between Dead Space and CO² Breathing in Humans

Ryoko Maruyama, Hidenori Masuyama, Yukio Tanaka, Yoshitake Nishibayashi, Yoshiyuki Honda

MED - Health Sciences

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

Ventilatory response during external dead space (tube) breathing and CO² inhalation for given increase in PET_CO2 were compared at different levels of PET_O2 (hyperoxia, normoxia, and hypoxia) in human subjects. At all the PET_O2 levels studied, magnitude of increment in minute ventilation (VE) and tidal volume were larger in the dead space breathing than in the CO² inhalation. The slope of CO²-ventilation response line was significantly steeper in the dead space breathing only in the hypoxic condition. There was no significant difference in frequency response to CO² between the two methods. These results suggested that augmented ventilatory response to CO² in the dead space breathing occurs in the condition of peripheral chemoreceptor activation.

Original language	English
Pages (from-to)	321-328
Number of pages	8
Journal	The Japanese journal of physiology
Volume	38
Issue number	3
DOIs	https://doi.org/10.2170/jjphysiol.38.321
Publication status	Published - 1988 Dec 12

Keywords

CO inhalation hypercapnia
dead space
peripheral chmoreceptors
respiratory control

ASJC Scopus subject areas

Physiology

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10.2170/jjphysiol.38.321

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Maruyama, R., Masuyama, H., Tanaka, Y., Nishibayashi, Y., & Honda, Y. (1988). Comparison of Ventilatory Response between Dead Space and CO² Breathing in Humans. The Japanese journal of physiology, 38(3), 321-328. https://doi.org/10.2170/jjphysiol.38.321

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