Comparison of Ventilatory Response between Dead Space and CO2 Breathing in Humans

Ryoko Maruyama; Hidenori Masuyama; Yukio Tanaka; Yoshitake Nishibayashi; Yoshiyuki Honda

doi:10.2170/jjphysiol.38.321

Comparison of Ventilatory Response between Dead Space and CO² Breathing in Humans

Ryoko Maruyama, Hidenori Masuyama, Yukio Tanaka, Yoshitake Nishibayashi, Yoshiyuki Honda

MED - Health Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Ventilatory response during external dead space (tube) breathing and CO² inhalation for given increase in PET_CO2 were compared at different levels of PET_O2 (hyperoxia, normoxia, and hypoxia) in human subjects. At all the PET_O2 levels studied, magnitude of increment in minute ventilation (VE) and tidal volume were larger in the dead space breathing than in the CO² inhalation. The slope of CO²-ventilation response line was significantly steeper in the dead space breathing only in the hypoxic condition. There was no significant difference in frequency response to CO² between the two methods. These results suggested that augmented ventilatory response to CO² in the dead space breathing occurs in the condition of peripheral chemoreceptor activation.

Original language	English
Pages (from-to)	321-328
Number of pages	8
Journal	The Japanese journal of physiology
Volume	38
Issue number	3
DOIs	https://doi.org/10.2170/jjphysiol.38.321
Publication status	Published - 1988 Dec 12

Keywords

CO inhalation hypercapnia
dead space
peripheral chmoreceptors
respiratory control

ASJC Scopus subject areas

Physiology

Access to Document

10.2170/jjphysiol.38.321

Cite this

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abstract = "Ventilatory response during external dead space (tube) breathing and CO2 inhalation for given increase in PETCO2 were compared at different levels of PETO2 (hyperoxia, normoxia, and hypoxia) in human subjects. At all the PETO2 levels studied, magnitude of increment in minute ventilation (VE) and tidal volume were larger in the dead space breathing than in the CO2 inhalation. The slope of CO2-ventilation response line was significantly steeper in the dead space breathing only in the hypoxic condition. There was no significant difference in frequency response to CO2 between the two methods. These results suggested that augmented ventilatory response to CO2 in the dead space breathing occurs in the condition of peripheral chemoreceptor activation.",

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AB - Ventilatory response during external dead space (tube) breathing and CO2 inhalation for given increase in PETCO2 were compared at different levels of PETO2 (hyperoxia, normoxia, and hypoxia) in human subjects. At all the PETO2 levels studied, magnitude of increment in minute ventilation (VE) and tidal volume were larger in the dead space breathing than in the CO2 inhalation. The slope of CO2-ventilation response line was significantly steeper in the dead space breathing only in the hypoxic condition. There was no significant difference in frequency response to CO2 between the two methods. These results suggested that augmented ventilatory response to CO2 in the dead space breathing occurs in the condition of peripheral chemoreceptor activation.

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