TY - JOUR
T1 - Comparison of Ventilatory Response between Dead Space and CO2 Breathing in Humans
AU - Maruyama, Ryoko
AU - Masuyama, Hidenori
AU - Tanaka, Yukio
AU - Nishibayashi, Yoshitake
AU - Honda, Yoshiyuki
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1988/12/12
Y1 - 1988/12/12
N2 - Ventilatory response during external dead space (tube) breathing and CO2 inhalation for given increase in PETCO2 were compared at different levels of PETO2 (hyperoxia, normoxia, and hypoxia) in human subjects. At all the PETO2 levels studied, magnitude of increment in minute ventilation (VE) and tidal volume were larger in the dead space breathing than in the CO2 inhalation. The slope of CO2-ventilation response line was significantly steeper in the dead space breathing only in the hypoxic condition. There was no significant difference in frequency response to CO2 between the two methods. These results suggested that augmented ventilatory response to CO2 in the dead space breathing occurs in the condition of peripheral chemoreceptor activation.
AB - Ventilatory response during external dead space (tube) breathing and CO2 inhalation for given increase in PETCO2 were compared at different levels of PETO2 (hyperoxia, normoxia, and hypoxia) in human subjects. At all the PETO2 levels studied, magnitude of increment in minute ventilation (VE) and tidal volume were larger in the dead space breathing than in the CO2 inhalation. The slope of CO2-ventilation response line was significantly steeper in the dead space breathing only in the hypoxic condition. There was no significant difference in frequency response to CO2 between the two methods. These results suggested that augmented ventilatory response to CO2 in the dead space breathing occurs in the condition of peripheral chemoreceptor activation.
KW - CO inhalation hypercapnia
KW - dead space
KW - peripheral chmoreceptors
KW - respiratory control
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U2 - 10.2170/jjphysiol.38.321
DO - 10.2170/jjphysiol.38.321
M3 - Article
C2 - 3141663
AN - SCOPUS:0023859339
VL - 38
SP - 321
EP - 328
JO - The Journal of Physiological Sciences
JF - The Journal of Physiological Sciences
SN - 1880-6546
IS - 3
ER -