Comparison of the effects of curcumin and curcumin glucuronide in human hepatocellular carcinoma HepG2 cells

Motomu Shoji, Kiyotaka Nakagawa, Akio Watanabe, Tsuyoshi Tsuduki, Teiko Yamada, Shigefumi Kuwahara, Fumiko Kimura, Teruo Miyazawa

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

Curcumin is a yellow pigment found in turmeric (Curcuma Longa L.), and is reported, in recent studies, to have several pharmacological effects, including anti-oxidant, anti-inflammatory, anti-tumour and lipid-lowering properties. However, as most curcumin is conjugated when absorbed through the intestine, free curcumin is present at extremely low levels inside the body. Therefore, curcumin metabolites have been presumed to be responsible for the curcumin bioactivity. In this study, we first confirmed that curcumin glucuronide is the major metabolite of curcumin found in the plasma after oral administration of curcumin in rats. Next, we synthesised curcumin glucuronide and compared the effects of curcumin and curcumin glucuronide on gene expression in a human hepatoma cell line (HepG2). We found that the effects of curcumin glucuronide are weaker than those of curcumin and that this difference is related to relative absorption rates of curcumin and curcumin glucuronide into HepG2 cells.

Original languageEnglish
Pages (from-to)126-132
Number of pages7
JournalFood Chemistry
Volume151
DOIs
Publication statusPublished - 2014 May 15

Keywords

  • Bioactivity
  • Curcumin
  • Glucuronide

ASJC Scopus subject areas

  • Analytical Chemistry
  • Food Science

Fingerprint Dive into the research topics of 'Comparison of the effects of curcumin and curcumin glucuronide in human hepatocellular carcinoma HepG2 cells'. Together they form a unique fingerprint.

Cite this