Comparison of spinal cord gray matter and white matter softness: Measurement by pipette aspiration method

Hiroshi Ozawa, Takeo Matsumoto, Toshiro Ohashi, Masaaki Sato, Shoichi Kokubun

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Object. Although the gray matter of the spinal cord has been thought to be softer than the white matter, there is no evidence to support this belief. Because the spinal cord is extremely soft, it has been difficult to measure the mechanical properties of the gray and white matter. The modulis of elasticity of the gray and white matter were measured in situ by using a pipette aspiration method. Method. The spinal cord specimens were excised from Japanese white rabbits. Specimens were cut to display the surfaces of axial, frontal, and sagittal sections. The surfaces of the gray and white matter were aspirated using a 0.8-mm-innerdiameter glass pipette while monitoring with a video microscope, and the deformed length in the pipette was measured on a monitor. In each case the modulus of elasticity was calculated by comparing the relationship between the aspiration pressure and aspirated volume of the specimen with that determined by finite element analysis. The moduli of elasticity of the gray and white matter were 3.4 ± 1.4 kPa (mean ± standard deviation) and 3.4 ± 0.9 kPa in the axial section, 3 ± 0.3 kPa and 3.5 ± 0.5 kPa in the frontal section, and 3.5 ± 0.9 kPa and 2.8 ± 0.4 kPa in the sagittal section, respectively. Conclusions. No significant difference in modulus of elasticity was shown between the gray and white matter of the spinal in sections made in various directions.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalJournal of neurosurgery
Volume95
Issue number2 SUPPL.
Publication statusPublished - 2001 Dec 1

Keywords

  • Aspiration
  • Gray matter
  • Modulus of elasticity
  • Spinal cord
  • White matter

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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    Ozawa, H., Matsumoto, T., Ohashi, T., Sato, M., & Kokubun, S. (2001). Comparison of spinal cord gray matter and white matter softness: Measurement by pipette aspiration method. Journal of neurosurgery, 95(2 SUPPL.), 221-224.