Comparison of Sedative Effects of Medetomidine-Midazolam, Acepromazine-Butorphanol and Midazolam-Butorphanol in Dogs

K. Kojima, R. Nishimura, T. Mutoh, K. Takao, S. Matsunaga, M. Mochizuki, N. Sasaki

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Sedative effects of medetomidine at 20 μg/kg and midazolam at 0.3 mg/kg (MM), acepromazine at 0.05 mg/kg and butorphanol at 0.2 mg/kg (AB), and midazolam at 0.1 mg/kg and butorphanol at 0.2 mg/kg (MB) were compared in dogs. All dogs given MM were laterally recumbent within 11 min of the administration of the drugs, and this combination also induced deep sedation accompanied by analgesia and muscle relaxation, and strongly depressed arousal reactions to external stimuli. However, undesirable effects such as bradycardia and decreased respiration were also observed in dogs given MM. Six of seven dogs given AB were laterally recumbert within 16 min of the administration of the drugs, and this combination induced relatively deep sedation but only a mild depression of arousal reactions to external stimuli. MB induced mild or moderate sedation with relatively large differences in effects among individuals. The recovery from sedation in each group was smooth and total recovery times were not significantly different.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalJournal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine
Volume46
Issue number3
DOIs
Publication statusPublished - 1999 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)

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