Comparison of regional brain volume and glucose metabolism between patients with mild dementia with lewy bodies and those with mild Alzheimer's disease

Kazunari Ishii, Tsutomu Soma, Atsushi K. Kono, Keitaro Sofue, Naokazu Miyamoto, Toshiki Yoshikawa, Etsuro Mori, Kenya Murase

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)

Abstract

The aim of this study was to investigate regional differences between morphologic and functional changes in patients with mild dementia with Lewy bodies (DLB) compared with those with Alzheimer's disease (AD). Methods: Twenty patients with very mild DLB (mean age, 74.5 y; mean Mini-Mental State Examination [MMSE] score, 24.0), 20 patients with very mild AD (mean age, 74.1 y; mean MMSE score, 24.0), and 20 age- and sex-matched healthy volunteers (normal controls [NC]) underwent both 18F-FDG PET and 3-dimensional spoiled gradient echo MRI. Fully automatic volumetry of the MRI data was used to obtain whole brain, hippocampal, occipital, and striatal volumes, which were compared with the results of a similar analysis of glucose metabolic data. Results: In DLB patients, volumetric data indicated a significant volume decrease in the striatum, whereas 18F-FDG PET showed significant glucose metabolic reductions in the temporal, parietal, and frontal areas - including in the occipital lobe - compared with those in the NC group. In contrast, in AD patients, both the hippocampal volume and glucose metabolism were significantly decreased, whereas the occipital volume and metabolism were preserved. Conclusion: Comparison of very mild DLB and AD revealed different morphologic and metabolic changes occurring in the medial temporal lobes and the occipital lobe, demonstrating characteristic pathophysiologic differences between these 2 diseases.

Original languageEnglish
Pages (from-to)704-711
Number of pages8
JournalJournal of Nuclear Medicine
Volume48
Issue number5
DOIs
Publication statusPublished - 2007 May 1

Keywords

  • Alzheimer's disease
  • Dementia
  • F-FDG
  • Glucose metabolism
  • Lewy bodies
  • MRI
  • PET
  • Volumetry

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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