Comparison of patients with invasive intraductal papillary mucinous carcinoma and invasive ductal carcinoma of the pancreas: a pathological type- and stage-matched analysis

Wataru Izumo, Ryota Higuchi, Toru Furukawa, Takehisa Yazawa, Shuichiro Uemura, Yutaro Matsunaga, Masahiro Shiihara, Masakazu Yamamoto

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Objective: We compared the pathological features and stage-matched outcomes of patients with invasive intraductal papillary mucinous carcinoma (IPMC) and invasive ductal carcinoma (IDC) of the pancreas to identify the reasons for these diseases’ differing prognoses. Methods: We analyzed 114 and 560 patients who underwent curative pancreatectomy for invasive IPMC and IDC, respectively, and analyzed their clinicopathological factors. Results: The disease-specific survival (DSS) of patients with invasive IPMC was significantly superior to that of patients with IDC exhibiting all pathological types at all stages. The DSS of patients with invasive IPMC exhibiting tubular adenocarcinoma was significantly superior to that of their counterparts with IDC only among those with stage IIB (p =.045). When comparing patients with stage IIB tubular adenocarcinoma-type invasive IPMC to their counterparts with IDC, the tumor size (2.6 cm vs. 3.3 cm, p =.010), serum level of carbohydrate antigen 19-9 (253 vs. 474 U/mL, p =.035), number of metastatic lymph nodes (3.1 vs. 4.5, p =.033), vascular invasion rate (14% vs. 41%, p =.0019) and local invasion rate (79% vs. 95%, p =.0045) were lower in the former group. Moreover, the frequency of pathological tubular adenocarcinoma grade 1 was higher in patients with invasive IPMC than in those with IDC (38% vs. 12%, p =.0004) as was the R0 resection rate (90% vs. 65%, p =.0027). Conclusions: In pathological type- and stage-matched analyses, invasive IPMC was associated with a better prognosis than IDC only in patients with stage IIB, as factors governing tumor aggressiveness were milder in the former group than in the latter.

Original languageEnglish
Pages (from-to)1412-1418
Number of pages7
JournalScandinavian journal of gastroenterology
Volume54
Issue number11
DOIs
Publication statusPublished - 2019 Nov 2

Keywords

  • Invasive intraductal papillary mucinous carcinoma
  • comparison
  • invasive ductal carcinoma

ASJC Scopus subject areas

  • Gastroenterology

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