Comparison of long-term clinical outcomes of CHOP chemotherapy between Japanese patients with nodal peripheral T-cell lymphomas and those with diffuse large B-cell lymphoma in the study group of the Tohoku Hematology Forum.

Tomoaki Akagi, Naoto Takahashi, Kouhei Yamaguchi, Kenichi Ishizawa, Kazunori Murai, Katsushi Tajima, Kazuhiko Ikeda, Yoshihiro Kameoka, Junnichi Kameoka, Shigeki Ito, Yuichi Kato, Hideyoshi Noji, Tsutomu Shichishima, Jugoh Itoh, Ryo Ichinohasama, Hideo Harigae, Yoji Ishida, Kenichi Sawada

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7 Citations (Scopus)

Abstract

To clarify the clinical outcome of peripheral T-cell lymphomas (PTCLs), we conducted a retrospective review comparing the outcomes of patients with PTCL (nodal peripheral T-cell lymphoma, unspecified, n=34 ; angioimmunoblastic T-cell lymphoma, n=12) to those with diffuse large B-cell lymphoma (DLBCL, n=48). All patients received CHOP-based chemotherapy without rituximab. PTCL patients presented at a more advanced clinical stage (91% vs. 65%, P<0.002) with a poorer performance status (26% vs. 17%, P<0.002) than DLBCL patients. The complete response rate among PTCL patients was significantly lower than among DLBCL patients (39% vs. 67%, P<0.008), as was the 3-year overall survival rate (26% vs. 50%, P=0.005), and Cox multivariate analysis revealed immunophenotype, performance status, and extranodal site involved to be significantly associated with shorter overall survival (P=0.045, P=0.007, and P=0.034, respectively). Our findings suggest that PTCL patients tend to have a poor prognosis associated with several initial risk factors. Moreover, the T-cell phenotype itself appears to have a significant impact on overall survival. Thus, standard CHOP chemotherapy may be inadequate for PTCLs, especially in patients with high-risk factors. The development of newly stratified therapies for the treatment of PTCLs would be highly desirable.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalJournal of clinical and experimental hematopathology : JCEH
Volume51
Issue number1
DOIs
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Medicine(all)

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