Comparison of label-free ACh-imaging sensors based on CCD and LAPS

Carl Frederik Werner, Shoko Takenaga, Hidenori Taki, Kazuaki Sawada, Michael J. Schöning

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Semiconductor-based chemical imaging sensors, like the light-addressable potentiometric sensor (LAPS) or the pH-imaging sensor based on a charge-coupled device (CCD), are becoming a powerful tool for label-free imaging of biological phenomena. We have proposed a polyion-based enzymatic membrane to develop an acetylcholine (ACh) imaging sensor for neural cell-activity observations. In this study, a CCD-type ACh-imaging sensor and a LAPS-type ACh-imaging sensor were fabricated and the prospect of both sensors was clarified by making a comparison of their basic characteristics.

Original languageEnglish
Pages (from-to)745-752
Number of pages8
JournalSensors and Actuators, B: Chemical
Volume177
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Acetylcholine
  • Charge-coupled device
  • Label-free imaging
  • Light-addressable potentiometric sensor
  • Polyion-complex membrane

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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