Comparison of intravenous tramadol and ketamine for prevention of catheter-related bladder discomfort after laparoscopic surgery: A randomized, placebo-controlled, double-blind study

Rattanaporn Burimsittichai, Phoonsak Limraksasin, Cameron Paul Hurst, Somrat Charuluxananan

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: Catheter-related bladder discomfort (CRBD) is a distressing symptom after anesthesia. Objectives: To compare the efficacy of tramadol and ketamine to prevent CRBD after laparoscopic surgery. Methods: After registration with the Thai Clinical Trial Registry (TCTR20140220001), we conducted a randomized controlled trial in 210 patients aged 18-70 years with American Society of Anesthesiologists physical status I or II undergoing elective laparoscopic surgery requiring bladder catheterization. These patients were randomly allocated into 1 of 3 groups: Group T received intravenous (i.v.) tramadol 1.5 mg/kg, Group K received i.v. ketamine 0.5 mg/kg, and Group P received i.v. saline as a placebo before catheterization. Patients received i.v. morphine for postoperative pain control. An anesthesiologist blinded to the randomization evaluated postoperative and CRBD pain severity using visual analog scales (VAS). The cumulative postoperative and CRBD pain was calculated by multiplying mean VA S scores by the hours of assessment. Results: Groups T and K had significantly less cumulative CRBD pain compared with placebo (P = 0.04 and 0.001, respectively). Cumulative postoperative pain, total 24-h morphine consumption, and adverse effects were comparable between groups. Group T had a significantly lower incidence of shoulder pain (7/67, 10%) than Group K (21/70, 30%), and Group P (24/70, 34%) 24 h after surgery (P = 0.006 and 0.001, respectively). Conclusions: Tramadol 1.5 mg/kg and ketamine 0.5 mg/kg administered i.v. before bladder catheterization are both effective in reducing the 24-h cumulative postoperative CRBD after laparoscopic surgery without significant adverse effects. Tramadol also decreases the incidence of postlaparoscopy shoulder pain.

Original languageEnglish
Pages (from-to)253-260
Number of pages8
JournalAsian Biomedicine
Volume10
Issue number3
DOIs
Publication statusPublished - 2016 Jun
Externally publishedYes

Keywords

  • Catheter-related bladder discomfort
  • Ketamine
  • Laparoscopic surgery
  • Laparoscopy
  • Pain
  • Prevention
  • Tramadol

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint

Dive into the research topics of 'Comparison of intravenous tramadol and ketamine for prevention of catheter-related bladder discomfort after laparoscopic surgery: A randomized, placebo-controlled, double-blind study'. Together they form a unique fingerprint.

Cite this