Comparison of immunosuppressive and cytotoxic cells in angiosarcoma: Development of a possible supportive therapy for angiosarcoma

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Abstract

An imbalance of immunosuppressive and cytotoxic cells plays an important role in inhibiting the anti-tumor immune response of the tumor-bearing host. The purpose of this study was to elucidate the involvement of immunosuppressive cells, such as regulatory T cells and CD163+ M2 macrophages as well as cytotoxic cells, such as granulysin-bearing cells and TIA-1+ cells in cutaneous angiosarcoma (AS) by immunohistochemical staining. In addition we evaluated the potencies of bisphosphonate, which was previously reported to suppress the expression of matrix metalloproteinase 9 (MMP-9), as a supportive therapy for AS together with docetaxel in 6 cases of cutaneous AS. These findings suggest that a high number of immunosuppressive cells might be related to the prognosis of AS, and that a combination of docetaxel with bisphosphonate risedronate sodium might be effective for MMP-9-expressing AS.

Original languageEnglish
Pages (from-to)14-20
Number of pages7
JournalDermatology
Volume227
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

Keywords

  • Angiosarcoma
  • CD163+ M2 macrophages
  • Matrix metalloproteinase 9
  • Regulatory T cells
  • Sodium risedronate hydrate

ASJC Scopus subject areas

  • Dermatology

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