Comparison of HAp and β-TCP in BMP-2 dose-response and release study

Junichi Tazaki, Toshiyuki Akazawa, Masaru Murata, Masaya Yamamoto, Yasuhiko Tabata, Jun Hino, Makoto Arisue, Takanori Shibata

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The aim of this study is to investigate in vivo local BMP-2 PK and bone induction in two bioceramics blocks (HAp, β-TCP), based on different composition and surface structures. We estimated the in vivo release profile of 125I-labeled BMP-2 and bone induction of hard tissues histologically. β-TCP is more effective for both BMP-2 retention and bone induction, compared to HAp, in the ectopic model.

Original languageEnglish
Pages (from-to)1033-1036
Number of pages4
JournalKey Engineering Materials
Volume361-363 II
Publication statusPublished - 2008 Jan 1
Externally publishedYes

Keywords

  • BMP-2
  • Dose-response
  • HAp
  • Release
  • β-TCP

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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