Comparison of HAp and β-TCP in BMP-2 dose-response and release study

Junichi Tazaki; Toshiyuki Akazawa; Masaru Murata; Masaya Yamamoto; Yasuhiko Tabata; Jun Hino; Makoto Arisue; Takanori Shibata

Comparison of HAp and β-TCP in BMP-2 dose-response and release study

Junichi Tazaki, Toshiyuki Akazawa, Masaru Murata, Masaya Yamamoto, Yasuhiko Tabata, Jun Hino, Makoto Arisue, Takanori Shibata

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The aim of this study is to investigate in vivo local BMP-2 PK and bone induction in two bioceramics blocks (HAp, β-TCP), based on different composition and surface structures. We estimated the in vivo release profile of ¹²⁵I-labeled BMP-2 and bone induction of hard tissues histologically. β-TCP is more effective for both BMP-2 retention and bone induction, compared to HAp, in the ectopic model.

Original language	English
Pages (from-to)	1033-1036
Number of pages	4
Journal	Key Engineering Materials
Volume	361-363 II
Publication status	Published - 2008 Jan 1
Externally published	Yes

Keywords

BMP-2
Dose-response
HAp
Release
β-TCP

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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AU - Tazaki, Junichi

AU - Akazawa, Toshiyuki

AU - Murata, Masaru

AU - Yamamoto, Masaya

AU - Tabata, Yasuhiko

AU - Hino, Jun

AU - Arisue, Makoto

AU - Shibata, Takanori

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KW - Dose-response

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KW - Release

KW - β-TCP

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