Comparison of HAp and β-TCP in BMP-2 dose-response and release study

Junichi Tazaki; Toshiyuki Akazawa; Masaru Murata; Masaya Yamamoto; Yasuhiko Tabata; Jun Hino; Makoto Arisue; Takanori Shibata

Comparison of HAp and β-TCP in BMP-2 dose-response and release study

Junichi Tazaki, Toshiyuki Akazawa, Masaru Murata, Masaya Yamamoto, Yasuhiko Tabata, Jun Hino, Makoto Arisue, Takanori Shibata

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The aim of this study is to investigate in vivo local BMP-2 PK and bone induction in two bioceramics blocks (HAp, β-TCP), based on different composition and surface structures. We estimated the in vivo release profile of ¹²⁵I-labeled BMP-2 and bone induction of hard tissues histologically. β-TCP is more effective for both BMP-2 retention and bone induction, compared to HAp, in the ectopic model.

Original language	English
Pages (from-to)	1033-1036
Number of pages	4
Journal	Key Engineering Materials
Volume	361-363 II
Publication status	Published - 2008
Externally published	Yes

Keywords

BMP-2
Dose-response
HAp
Release
β-TCP

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

Cite this

@article{2a3f3f9a6d8740439a0a976e72d0a201,

title = "Comparison of HAp and β-TCP in BMP-2 dose-response and release study",

abstract = "The aim of this study is to investigate in vivo local BMP-2 PK and bone induction in two bioceramics blocks (HAp, β-TCP), based on different composition and surface structures. We estimated the in vivo release profile of 125I-labeled BMP-2 and bone induction of hard tissues histologically. β-TCP is more effective for both BMP-2 retention and bone induction, compared to HAp, in the ectopic model.",

keywords = "BMP-2, Dose-response, HAp, Release, β-TCP",

author = "Junichi Tazaki and Toshiyuki Akazawa and Masaru Murata and Masaya Yamamoto and Yasuhiko Tabata and Jun Hino and Makoto Arisue and Takanori Shibata",

year = "2008",

language = "English",

volume = "361-363 II",

pages = "1033--1036",

journal = "Key Engineering Materials",

issn = "1013-9826",

publisher = "Trans Tech Publications",

}

TY - JOUR

T1 - Comparison of HAp and β-TCP in BMP-2 dose-response and release study

AU - Tazaki, Junichi

AU - Akazawa, Toshiyuki

AU - Murata, Masaru

AU - Yamamoto, Masaya

AU - Tabata, Yasuhiko

AU - Hino, Jun

AU - Arisue, Makoto

AU - Shibata, Takanori

PY - 2008

Y1 - 2008

N2 - The aim of this study is to investigate in vivo local BMP-2 PK and bone induction in two bioceramics blocks (HAp, β-TCP), based on different composition and surface structures. We estimated the in vivo release profile of 125I-labeled BMP-2 and bone induction of hard tissues histologically. β-TCP is more effective for both BMP-2 retention and bone induction, compared to HAp, in the ectopic model.

AB - The aim of this study is to investigate in vivo local BMP-2 PK and bone induction in two bioceramics blocks (HAp, β-TCP), based on different composition and surface structures. We estimated the in vivo release profile of 125I-labeled BMP-2 and bone induction of hard tissues histologically. β-TCP is more effective for both BMP-2 retention and bone induction, compared to HAp, in the ectopic model.

KW - BMP-2

KW - Dose-response

KW - HAp

KW - Release

KW - β-TCP

UR - http://www.scopus.com/inward/record.url?scp=38149062737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38149062737&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:38149062737

VL - 361-363 II

SP - 1033

EP - 1036

JO - Key Engineering Materials

JF - Key Engineering Materials

SN - 1013-9826

ER -

Comparison of HAp and β-TCP in BMP-2 dose-response and release study

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this