Comparison of Gefitinib Versus Chemotherapy in Patients with Non-small Cell Lung Cancer with Exon 19 Deletion

Satoshi Watanabe, Akira Inoue, Toshihiro Nukiwa, Kunihiko Kobayashi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

BACKGROUND: Second-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) afatinib as first-line treatment has been demonstrated to improve overall survival (OS) in patients with non-small cell lung cancer (NSCLC) harboring an exon 19 deletion (del19) of EGFR compared to platinum-doublet chemotherapy. However, it is unclear whether first-generation EGFR-TKIs improve OS in patients with del19 in the first-line treatment.

PATIENTS AND METHODS: We performed a post-hoc analysis of patients with del19 or L858R mutation of EGFR who received gefitinib in the NEJ002 study, which compared gefitinib to carboplatin-paclitaxel.

RESULTS: A total of 58 patients and 57 patients with del19 EGFR received gefitinib and carboplatin-paclitaxel, respectively. No OS differences were observed between patients receiving gefitinib and carboplatin-paclitaxel irrespective of del19 (29.3 months vs. 29.7 months, p=0.53) or L858R (28.4 months vs. 25.1 months, p=0.45).

CONCLUSION: In contrast to afatinib, it is suggested that first-line gefitinib does not improve OS in patients with del19 of EGFR compared with platinum-doublet chemotherapy.

Original languageEnglish
Pages (from-to)6957-6961
Number of pages5
JournalAnticancer research
Volume35
Issue number12
Publication statusPublished - 2015 Dec 1
Externally publishedYes

Keywords

  • EGFR mutation
  • Gefitinib
  • L858R
  • exon 19 deletion
  • non-small cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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