Comparison of Foxp3+regulatory T cells and CD163+ macrophages in invasive and non-invasive extramammary paget's disease

Taku Fujimura, Yumi Kambayashi, Takanori Hidaka, Akira Hashimoto, Takahiro Haga, Setsuya Aiba

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Regulatory T cells (Tregs), identified by the expression of CD4, CD25 and Foxp3, together with immunosuppressive macrophages, such as CD163+ M2 macrophages, are involved in maintaining peripheral tolerance. The aim of this study was to elucidate the involvement of Tregs and CD163+ macrophages in invasive and noninvasive extramammary Paget's disease. The presence of CD4+CD25+Foxp3+ Tregs, CD163+ M2 macrophages and matrix metalloproteinase-9+ cells was examined immunohistologically in fixed sections of lesional skin from 10 patients with non-invasive extramammary Paget's disease and 7 patients with invasive extramammary Paget's disease. Fewer CD4+CD25+Foxp3+ Tregs were observed in non-invasive extramammary Paget's disease than in invasive extramammary Paget's disease. In contrast, higher numbers of CD163+ macrophages and metalloproteinase-9+ cells were detected only in invasive extramammary Paget's disease. These findings suggest that the induction of immunosuppressive cells in extramammary Paget's disease differs according to the tumour stage.

Original languageEnglish
Pages (from-to)625-628
Number of pages4
JournalActa Dermato-Venereologica
Issue number6
Publication statusPublished - 2012


  • CD163
  • Foxp3
  • Macrophages
  • Matrix metalloproteinase-9
  • Regulatory T cells

ASJC Scopus subject areas

  • Dermatology

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