Comparison of CRH test and ACTH test in patients with bronchial asthma

Takao Iwasaki, G. Tamura, K. Sano, Y. Ohkawara, K. Haneda, K. Shirato

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Although glucocorticoid is the most effective agent for bronchial asthma, its systemic administration leads to suppression of adrenocortical function. Rapid ACTH test has been performed for assessing the function of the hypothalamic-pituitary-adrenocortical (HPA) system of asthmatics. Recently human corticotropin-releasing hormone (CRH) has been chemically synthesized. In order to evaluate clinical usefulness of CRH, we compared CRH test with ACTH test in 17 patients with bronchial asthma (3 patients out of them concurrently receiving prednisolone 5-10 mg/day). Both tests were carried out within 2 weeks after 6 month treatment with fluticasone propionate (800 μg/day) inhaled via pMDI. There is no significant difference between results obtained from the both tests. Thus, dividing subjects into high and low responders based on an extent of increases in plasma ACTH levels after the CRH injection, we found a significant difference in maximal plasma concentrations of cortisol between after CRH and ACTH injections in the low responders. Therefore, in some patients, CRH test provides more accurate assessment of the function of HPA system than ACTH test.

    Original languageEnglish
    Pages (from-to)632-638
    Number of pages7
    JournalJapanese Journal of Allergology
    Volume48
    Issue number6
    Publication statusPublished - 1999 Jul 28

    Keywords

    • ACTH test
    • Asthma
    • CRH test
    • Fluticasone propionate

    ASJC Scopus subject areas

    • Immunology and Allergy

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  • Cite this

    Iwasaki, T., Tamura, G., Sano, K., Ohkawara, Y., Haneda, K., & Shirato, K. (1999). Comparison of CRH test and ACTH test in patients with bronchial asthma. Japanese Journal of Allergology, 48(6), 632-638.