Comparison of Cardiopulmonary Effects of Medetomidine-Midazolam, Acepromazine-Butorphanol and Midazolam-Butorphanol in Dogs

K. Kojima, R. Nishimura, T. Mutoh, K. Takao, S. Matsunaga, M. Mochizuki, N. Sasaki

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Cardiopulmonary effects of intramuscualar administration of medetomidine-midazolam at 20 μg/kg and 0.3 mg/kg, respectively (MM), acepromazine-butorphanol at 0.05 and 0.2 mg/kg, respectively (AB), and midazolam-butorphanol at 0.1 and 0.2 mg/kg, respectively (MB), were compared in dogs. MM produced relatively large cardiovascular changes such as bradycardia, hypertension, a decrease in cardiac output and vasoconstriction. AB produced moderate cardiovascular changes. Hypotension was observed within 5 min after administration and the mean arterial blood pressure decreased by 30 % at 20 min after administration. MB produced decreases in arterial blood pressure and cardiac output, but these changes were small and, of the combinations evaluated in this study, MB had the mildest cardiovascular effects.

Original languageEnglish
Pages (from-to)353-359
Number of pages7
JournalJournal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine
Volume46
Issue number6
DOIs
Publication statusPublished - 1999 Aug
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)

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