Comparison of bone regeneration between octacalcium phosphate/collagen composite and β-tricalcium phosphate in canine calvarial defect

Yuji Tanuma, Keiko Matsui, Tadashi Kawai, Aritsune Matsui, Osamu Suzuki, Shinji Kamakura, Seishi Echigo

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: The present study evaluated the efficacy of bone regeneration between synthetic octacalcium phosphate (OCP) granules combined with porcine atelocollagen (OCP/Col) and β-tricalcium phosphate (β-TCP). Study Design: A disk of OCP/Col (20 mm diameter, 2.5 mm thick) or commercially available sintered porous β-TCP was implanted into a critical-sized calvarial defect (20 mm diameter) of adult male canines (n = 10). The newly formed bone in the defect was analyzed radiographically, crystallographically, histologically, and histomorphometrically at 6 months after implantation. Results: Histomorphometry showed that there was significantly more newly formed bone in OCP/Col-treated defects than for β-TCP (P <.05). X-Ray diffraction patterns of implanted OCP/Col were similar to those of original bone and different from those of implanted β-TCP. Conclusions: These results suggest that OCP/Col implantation in canine critical-sized defect enhanced bone regeneration more than β-TCP, which is the most commonly used synthetic bone substitutes.

Original languageEnglish
Pages (from-to)9-17
Number of pages9
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume115
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging

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