Comparison between in vivo and in vitro pharmacokinetics of succinylcholine in humans

M. Kato, T. Shiratori, M. Yamamuro, S. Haga, K. Hoshi, S. Matsukawa, I. M. Jalal, Y. Hashimoto

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Purpose. To compare the in vivo and in vitro pharmacokinetics of succinylcholine (SCh) in humans. Methods. A bolus of SCh 1 mg · kg-1 (n = 7) or 2 mg · kg-1 (n = 11) was given to 18 patients anesthetized with thiopental. Arterial blood samples for determination of in vivo SCh concentrations were collected every 30 s for 5 min. Another 20-ml blood sample was obtained before induction of anesthesia for determination of in vitro SCh. Concentrations of SCh were measured by high-performance liquid chromatography. In vivo and in vitro concentrations of SCh vs time data were analyzed by the one-compartment model. Results. The respective in vivo and in vitro pharmacokinetic parameters (SCh 1 mg · kg-1 vs SCh 2 mg · kg-1) were as follows: Plasma clearance was 4.17 ± 2.37 and 1.85 ± 0.281 · min-1, P < 0.05, vs 2.91 ± 2.01 and 1.27 ± 0.431 · min-1, P < 0.05. Elimination half-life was 25.4 ± 10.6 and 47.4 ± 5.4 s, P < 0.002 vs 26.3 ± 10.0 and 75.2 ± 21.8 s, P < 0.00005. Conclusion. These results suggest that the rapid disappearance of SCh from the circulation is due to diffusion out of the blood vessels rather than to enzymatic hydrolysis.

Original languageEnglish
Pages (from-to)189-192
Number of pages4
JournalJournal of Anesthesia
Volume13
Issue number4
DOIs
Publication statusPublished - 1999

Keywords

  • Cholinesterase
  • Pharmacokinetics
  • Succinylcholine

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Comparison between in vivo and in vitro pharmacokinetics of succinylcholine in humans'. Together they form a unique fingerprint.

Cite this