Comparative study on the influence of bases on (3-N-[11C]methyl)spiperone synthesis

Claudio Pascali; Ren Iwata; Tatsuo Ido

doi:10.1016/0883-2889(92)90185-H

Comparative study on the influence of bases on (3-N-[¹¹C]methyl)spiperone synthesis

Claudio Pascali, Ren Iwata, Tatsuo Ido

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A series of preparations of (3-N-[¹¹C]methyl)spiperone in several basis conditions by means of an automated system incorporating an "on-line" methylation is reported. The radiochemical yield was observed to be strongly affected by the water content. For all the preparations the reaction temperature was 80°C and the reaction time 5 min. The influence of these two parameters on the radiochemical yield for the synthesis utilizing methanolic tetrabutylammonium hydroxide has been briefly examined.

Original language	English
Pages (from-to)	1526-1528
Number of pages	3
Journal	International Journal of Radiation Applications and Instrumentation. Part
Volume	43
Issue number	12
DOIs	https://doi.org/10.1016/0883-2889(92)90185-H
Publication status	Published - 1992 Dec

ASJC Scopus subject areas

Radiation
Engineering(all)

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abstract = "A series of preparations of (3-N-[11C]methyl)spiperone in several basis conditions by means of an automated system incorporating an {"}on-line{"} methylation is reported. The radiochemical yield was observed to be strongly affected by the water content. For all the preparations the reaction temperature was 80°C and the reaction time 5 min. The influence of these two parameters on the radiochemical yield for the synthesis utilizing methanolic tetrabutylammonium hydroxide has been briefly examined.",

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year = "1992",

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AU - Iwata, Ren

AU - Ido, Tatsuo

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N2 - A series of preparations of (3-N-[11C]methyl)spiperone in several basis conditions by means of an automated system incorporating an "on-line" methylation is reported. The radiochemical yield was observed to be strongly affected by the water content. For all the preparations the reaction temperature was 80°C and the reaction time 5 min. The influence of these two parameters on the radiochemical yield for the synthesis utilizing methanolic tetrabutylammonium hydroxide has been briefly examined.

AB - A series of preparations of (3-N-[11C]methyl)spiperone in several basis conditions by means of an automated system incorporating an "on-line" methylation is reported. The radiochemical yield was observed to be strongly affected by the water content. For all the preparations the reaction temperature was 80°C and the reaction time 5 min. The influence of these two parameters on the radiochemical yield for the synthesis utilizing methanolic tetrabutylammonium hydroxide has been briefly examined.

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Comparative study on the influence of bases on (3-N-[¹¹C]methyl)spiperone synthesis

Abstract

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