Comparative study on the influence of bases on (3-N-[11C]methyl)spiperone synthesis

Claudio Pascali; Ren Iwata; Tatsuo Ido

doi:10.1016/0883-2889(92)90185-H

Comparative study on the influence of bases on (3-N-[¹¹C]methyl)spiperone synthesis

Claudio Pascali, Ren Iwata, Tatsuo Ido

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A series of preparations of (3-N-[¹¹C]methyl)spiperone in several basis conditions by means of an automated system incorporating an "on-line" methylation is reported. The radiochemical yield was observed to be strongly affected by the water content. For all the preparations the reaction temperature was 80°C and the reaction time 5 min. The influence of these two parameters on the radiochemical yield for the synthesis utilizing methanolic tetrabutylammonium hydroxide has been briefly examined.

Original language	English
Pages (from-to)	1526-1528
Number of pages	3
Journal	International Journal of Radiation Applications and Instrumentation. Part
Volume	43
Issue number	12
DOIs	https://doi.org/10.1016/0883-2889(92)90185-H
Publication status	Published - 1992 Dec

ASJC Scopus subject areas

Radiation
Engineering(all)

Access to Document

10.1016/0883-2889(92)90185-H

Fingerprint Dive into the research topics of 'Comparative study on the influence of bases on (3-N-[<sup>11</sup>C]methyl)spiperone synthesis'. Together they form a unique fingerprint.

Cite this

@article{bac41556bfed49de887abde521ac515c,

title = "Comparative study on the influence of bases on (3-N-[11C]methyl)spiperone synthesis",

abstract = "A series of preparations of (3-N-[11C]methyl)spiperone in several basis conditions by means of an automated system incorporating an {"}on-line{"} methylation is reported. The radiochemical yield was observed to be strongly affected by the water content. For all the preparations the reaction temperature was 80°C and the reaction time 5 min. The influence of these two parameters on the radiochemical yield for the synthesis utilizing methanolic tetrabutylammonium hydroxide has been briefly examined.",

author = "Claudio Pascali and Ren Iwata and Tatsuo Ido",

year = "1992",

month = dec,

doi = "10.1016/0883-2889(92)90185-H",

language = "English",

volume = "43",

pages = "1526--1528",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Limited",

number = "12",

}

TY - JOUR

T1 - Comparative study on the influence of bases on (3-N-[11C]methyl)spiperone synthesis

AU - Pascali, Claudio

AU - Iwata, Ren

AU - Ido, Tatsuo

PY - 1992/12

Y1 - 1992/12

N2 - A series of preparations of (3-N-[11C]methyl)spiperone in several basis conditions by means of an automated system incorporating an "on-line" methylation is reported. The radiochemical yield was observed to be strongly affected by the water content. For all the preparations the reaction temperature was 80°C and the reaction time 5 min. The influence of these two parameters on the radiochemical yield for the synthesis utilizing methanolic tetrabutylammonium hydroxide has been briefly examined.

AB - A series of preparations of (3-N-[11C]methyl)spiperone in several basis conditions by means of an automated system incorporating an "on-line" methylation is reported. The radiochemical yield was observed to be strongly affected by the water content. For all the preparations the reaction temperature was 80°C and the reaction time 5 min. The influence of these two parameters on the radiochemical yield for the synthesis utilizing methanolic tetrabutylammonium hydroxide has been briefly examined.

UR - http://www.scopus.com/inward/record.url?scp=0026469086&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026469086&partnerID=8YFLogxK

U2 - 10.1016/0883-2889(92)90185-H

DO - 10.1016/0883-2889(92)90185-H

M3 - Article

AN - SCOPUS:0026469086

VL - 43

SP - 1526

EP - 1528

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

SN - 0969-8043

IS - 12