Comparative study on the efficacy of S-1108 and cefotiam hexetil in bacterial pneumonia

Atsushi Saito, Hiroshi Fukuhara, Jun Inadome, Hiroaki Nakamura, Akiko Miyazato, Yoshikazu Kawakami, Etsuro Yamaguchi, Akira Saito, Ichiro Nakayama, Masumi Tomizawa, Yohmei Hiraga, Mitsuhide Ohmichi, Kazuo Takebe, Toyokazu Tamura, Mitsuo Masuda, Masashi Tamura, Kazuki Konishi, Kazuo Obara, Kenichi Takeuchi, Masafumi MasudaHaruto Hirano, Akira Watanabe, Kiyoshi Konno, Tsuneo Sayama, Satoru Shoji, Mitsunobu Honma, Kaoru Shimada, Norio Kikuchi, Atsushi Saito, Kohya Shiba, Osamu Sakai, Hiroyuki Kobayashi, Susumu Sakayori, Izumi Hayashi, Masaru Koyama, Yoshio Uzuka, Harumi Shishido, Takeshi Yamaryo, Kazuhiko Someya, Satoru Takahashi, Yoshiaki Nagayama, Shoichiro Irimajiri, Mitsuo Obana, Fumio Matsumoto, Takeo Imai, Shigeki Odagiri, Kenichi Takahashi, Takashi Ogura, Masaaki Arakawa, Kouichi Wada, Fumihide Iwata, Shigeyuki Hoshino, Hiroki Tukada, Nobuki Aoki, Osamu Sekine, Yasutoshi Suzuki, Kaoru Shimokata, Shuzo Sakai, Fumio Nomura, Hironobu Minami, Kazuyoshi Senda, Masashi Yamamoto, Toshiyuki Yamamoto, Kanzo Suzuki, Toru Matsuura, Shigeru Shirakawa, Fumio Miki, Kojiro Yasunaga, Seibun Yonezu, Yoshitaka Yamanaka, Yasuhiko Miyazaki, Nobuhiro Narita, Masayoshi Sawaki, Keiichi Mikasa, Rinzo Soejima, Toshiharu Matsushima, Makoto Kimura, Michio Yamakido, Soichiro Hozawa, Hideto Yamakido, Yoshiro Sawae, Koji Takaki, Yukio Kumagai, Satoshi Kuboi, Toshiyuki Ishimaru, Kotaro Oizumi, Yoichiro Ichikawa, Naoto Tokunaga, Kohei Hara, Shigeru Kohno, Hironobu Koga, Mitsuo Kaku, Kazunori Tomono, Naomi Ito, Osamu Sakito, Keizo Matsumoto, Tsuyoshi Nagatake, Naoto Rikitomi, Yoshiaki Utsunomiya, Masaru Nasu, Jun Goto, Kazuo Kitagawa, Mitsuyoshi Nakashima, Intetsu Kobayashi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To evaluate the efficacy, safety and usefulness of S-1108, a new ester-type oral cephem antibiotic, in bacterial pneumonia, we carried out a double-blind comparative study with cefotiam hexetil (CTM-HE) in collaborating institutions. S-1108 at a daily dose of 450 mg (divided in 3 doses) and CTM-HE at a daily dose of 600 mg (divided in 3 doses) were orally administrated for 14 days, and the following results were obtained: 1) The number of patients who were given the study drugs was 132 (S-1108 group: 64, CTM-HE group: 68). The number of evaluable patients for clinical efficacy, side effects, abnormal laboratory values and usefulness were 108 (S-1108 group: 49, CTM-HE group: 59), 126 (S-1108 group: 61, CTM-HE group: 65), 114 (S-1108 group: 61, CTM-HE group: 53) and 109 (S-1108 group: 49, CTM-HE group: 60), respectively. 2) The efficacy rates for bacterial pneumonia were 90.9% in the S-1108 group and 82.1% in the CTM-HE group, showing no significant differences between the two groups. 3) There were no significant differences between the two groups with respect to the degree of improvement in subjective and objective signs, or laboratory values except for ESR on the 7 th and 14 th day of treatment (p=0.0009 and p=0.0068, respectively), and CRP on the 3 rd day and 14th day of treatment (p=0.0160 and p=0.0440, respectively) in all of which S-1108 was superior. 4) As for the bacteriological effects, the elimination rates of causative organisms were 94.7% in the S-1108 group and 73.1% in the CTM-HE group, with no significant differences. 5) Side effects were observed in 3 patients (4.9%) in the S-1108 group and 5 patients (7.7%) in the CTM-HE group, and abnormal changes in laboratory findings in 18 patients (29.5%) in the S-1108 group and 10 patients (18.9%) in the CTM-HE group, again showing no significant differences. 6) The utility rates (satisfaction rate) for bacterial pneumonia were 90.9% in the S-1108 group and 77.2% in the CTM-HE group, with no significant differences between the two groups. The above results indicate that S-1108 in daily doses of 450 mg is as useful as CTM-HE in daily doses of 600 mg in the treatment of bacterial pneumonia.

Original languageEnglish
Pages (from-to)451-475
Number of pages25
JournalChemotherapy
Volume42
Issue number4
DOIs
Publication statusPublished - 1994

Keywords

  • Bacterial penumoniae
  • Double blind study
  • S-1108
  • cefotiam hexetil

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery
  • Oncology

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  • Cite this

    Saito, A., Fukuhara, H., Inadome, J., Nakamura, H., Miyazato, A., Kawakami, Y., Yamaguchi, E., Saito, A., Nakayama, I., Tomizawa, M., Hiraga, Y., Ohmichi, M., Takebe, K., Tamura, T., Masuda, M., Tamura, M., Konishi, K., Obara, K., Takeuchi, K., ... Kobayashi, I. (1994). Comparative study on the efficacy of S-1108 and cefotiam hexetil in bacterial pneumonia. Chemotherapy, 42(4), 451-475. https://doi.org/10.11250/chemotherapy1953.42.451