Comparative study on the effectiveness of bacampicillin and amoxicillin on pneumonia by double blind method

Kenzo Shiota, Fumio Miki, Tomokazu Asai, Kenji Kubo, Masakazu Kono, Kenji Takamatsu, Yasumichi Kato, Akira Saito, Ichiro Nakayama, Masumi Tomizawa, Tatsunori Shimizu, Fumio Nagahama, Tetsushi Koroku, Shinya Yasuda, Takashi Mikami, Norimichi Konno, Yasumasa Yokota, Masahiro Tsuji, Kazunori Harada, Seiji AbeKazuo Takebe, Kenichi Imamura, Muneki Sakakura, Masayoshi Kobayashi, Kenichi Kimura, Shuichiro Yoshida, Ichiro Hirai, Shiro Kosaka, Mitsuaki Yoshioka, Hitoshi Takishima, Sumio Arai, Kiyoshi Konno, Kotaro Oizumi, Akira Watanabe, Seiichi Aonuma, Hajimu Takeda, Shiro Kawashima, Osamu Sekine, Yoshimaru Usuda, Nobuki Aoki, Yutaka Kanazawa, Masataka Katsu, Shinji Okui, Hisashi Takizuka, Ryoichi Muraki, Keimei Mashimo, Otohiko Kunii, Kazufuto Fukaya, Keiichi Nakagawa, Kentaro Watanabe, Tatsuo Suzuki, Masaru Koyama, Norio Kihara, Kaoru Shimada, Katsumi Nakazawa, Kyoko Kazima, Yasushi Ueda, Osamu Kitamoto, Hiroyuki Kobayashi, Junzaburo Kabe, Ippei Fujimori, Toshio Sekimoto, Fuyuhiko Higashi, Toshiyuki Yamamoto, Masahito Kato, Saburo Kitaura, Yukio Goto, Masaru Onuma, Kaoru Oyama, Michiko Kanaki, Nobuo Maekawa, Michiyasu Nakanishi, Hiroshi Okubo, Yuruko Okamoto, Fumihiko Uba, Yoshihiro Ueda, Keigo Maehara, Takehiro Tsujimoto, Kenichi Shimizu, Hiroshi Maruyama, Natsuo Nishizawa, Tadayuki Terada, Rinzo Soejima, Yoshihiko Tano, Kenichi Shigeji, Yoshito Niki, Osamu Kurimura, Naomi Kimura, Eiro Tsubura, Toshihiro Goto, Katsuhito Kozai, Yoshihiro Takishita, Masakazu Tamura, Takuki Hashimoto, Seizaburo Taoka, Yoshihiro Sawae, Tsuneo Ishibashi, Masahiro Takamoto, Nobuyoshi Miyazaki, Kohei Hara, Masaru Nasu, Tsuneo Tsutsumi, Masao Nakatomi, Kinichi Izumikawa, Keizo Matsumoto, Hiroshi Suzuki, Harumi Shishido, Kimitoshi Tamaki

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    In order to compare the efficacy and side effects of Bacampicillin (BAPC) with those of Amoxicillin (AMPC), a comparative clincal trial has been carried out upon pneumonia at 35 institutions all over the country by means of a double-blind method. BAPC and AMPC were orally administered to 153 patients with pneumonia at a daily dose of 1g for 14 days. A statistical analysis between the two drugs was made on the efficacy in 116 cases excluding the cases which deviated rules of the protocol and on side effects in 147 cases excluding the cases which deviated rules of the protocol. Furthermore, a statistical analysis between the two drugs was also made on the efficacy, side effects, and utility in almost all cases according to the judgement by doctors in charge. The results are as follows: 1. The clinical efficacy of BAPC at the daily dose of 1g was equal to that of AMPC in the treatment of pneumonia. 2. Regarding the degree of improvement of symptoms and laboratory test data, no significant difference was observed between the two groups except for the superiority of AMPC over BAPC in tne degree of improvement in CRP at the end of treatment. 3. No significant difference was observed between both groups in the occurrence of side effects.

    Original languageEnglish
    Pages (from-to)725-759
    Number of pages35
    JournalChemotherapy
    Volume27
    Issue number5
    DOIs
    Publication statusPublished - 1979

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

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  • Cite this

    Shiota, K., Miki, F., Asai, T., Kubo, K., Kono, M., Takamatsu, K., Kato, Y., Saito, A., Nakayama, I., Tomizawa, M., Shimizu, T., Nagahama, F., Koroku, T., Yasuda, S., Mikami, T., Konno, N., Yokota, Y., Tsuji, M., Harada, K., ... Tamaki, K. (1979). Comparative study on the effectiveness of bacampicillin and amoxicillin on pneumonia by double blind method. Chemotherapy, 27(5), 725-759. https://doi.org/10.11250/chemotherapy1953.27.725