Comparative studies on activities of antimicrobial agents against causative organisms isolated from urinary tract infections (1992): I. Susceptibility distribution

Yoshiaki Kumamoto, Takaoki Hirose, Noriaki Tanaka, Yoshinao Hikichi, Shiro Shigeta, Yasuo Shiraiwa, Hiroshi Kameoka, Hiroshi Yoshida, Masahiro Ogata, Hiroshi Tazaki, Hisami Iri, Hiroshi Uchida, Yoshio Kobayashi, Seiji Matsuda, Ryuichi Kitagawa, Makoto Fujime, Kazuhiko Fujita, Jun Igari, Toyoko Oguri, Nozomu KosakaiKeizo Yamaguchi, Chikako Mochida, Taro Furusawa, Yasuko Takeuchi, Hiromi Moriyama, Kikutaro Shibata, Seibun Yonezu, Minato Takaha, Kiyomi Matsumiya, Michio Tanaka, Mitsuo Kaku, Kazuyuki Sugawara

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 732 bacterial strains isolated from patients with urinary tract infections in 11 hospitals during the period of June 1992 to May 1993. Of the above total bacterial isolates, Gram-positive bacteria accounted for 35.4% and a majority of them were Enterococcus faecalis. Gram-negative bacteria accounted for 64.6% and most of them were Escherichia coli. 1. Enterococcus faecalis Ampicillin (ABPC), imipenem (IPM) and vancomycin (VCM) showed the highest activities against E. faecalis isolated from patients with urinary tract infections. The mic90s of them were 2 µg/ml. Piperacillin (PIPC) was also active with the MIC90 of 8 µg/ml. The others except chloramphenicol (CP) were not so active with the MIC90s of 32 µg/ml or above. 2. Staphylococcus aureus including MRSA VCM showed the highest activities against S. aureus isolated from patients with urinary tract infections. Its MIC90 was 1 µg/ml. Arbekacin (ABK) was also active with the MIC90 of 2 µg/ml. The others were not so active with the MIC90s of 32 µg/ml or above. 3. Staphylococcus epidermidis ABK showed the highest activities against S. epidermidis isolated from patients with urinary tract infections. Its MIC90 was 0.5 µg/ml. Cefotiam (CTM) and VCM were also active with the MIC90s of 2 µg/ml. Penicillins except ABPC, gentamicin (GM), clindamycin (CLDM) and quinolones were not so active with the MIC90s of 64 µg/ml or above. 4. Streptococcus agalactiae Most of the agents were active against S. agalactiae isolated from patients with urinary tract infections. Penicillins, cephems, erythromycin (EM), and CLDM showed the highest activities. The MIC90s of them were 0.25 µg/ml or below. Amikacin (AMK) and minocycline (MINO) were not so active with the MIC90s of 32 µg/ml or above. 5. Citrobacter freundii IPM showed the highest activities against C. freundii isolated from patients with urinary tract infections. Its MIC90 was 1 µg/ml. Cefozopran (CZOP) and amikacin (AMK) were also active with the MIC90s of 4 µg/ml. Penicillins and cephems generally were not so active. 6. Enterobacter cloacae IPM and GM showed the highest activities against E. cloacae. The MIC90s of them were 0.5 µg/ml. Ciprofloxacin (CPFX) and tosufloxacin (TFLX) were also active with the MIC90s of 4 µg/ml. Penicillins and cephems generally showed lower activities. 7. Escherichia coli Most of the agents were active against E. coli. Flomoxef (FMOX), cefmenoxime (CMX), CZOP, IPM, carumonam (CRMN), norfloxacin (NFLX), ofloxacin (OFLX), CPFX and TFLX showed the highest activities against E. coli. The MIC90s of them were 0.125 µg/ml or below. Cefotiam (CTM), ceftazidime (CAZ), cefuzonam (CZON) and latamoxef (LMOX) were also active with the MIC90s of 0.25 µg/ml. Penicillins were not so active with the MIC90s of 32 µg/ml or above. 8. Klebsiella pneumoniae Most of the agents were active against K pneumoniae. FMOX, CMX, CZOP and CRMN showed the highest activities. The MIC90s of them were 0.125 µg/ml or below. But ampicillin (ABPC) was not so active with the MIC90 of 128 µg/ml. 9. Proteus mirabilis Most of the agents were active against P. mirabilis. FMOX, CMX, CAZ, CZON, LMOX, CFIX, CPDX, CRMN, NFLX, CPFX and TFLX showed the highest activities against P. mirabilis isolated from patients with urinary tract infections. The MIC90s of them were 0.125 µg/ml or below. ABPC and MINO were not so active with the MIC90s of 256 µg/ml or above. 10. Pseudomonas aeruginosa Most of the agents were not so active against P. aeruginosa. IPM showed MIC90 of 8 µg/ml. Cefclidin (CFCL) and AMK showed MIC90s of 16 µg/ml. IPM and TOB showed MIC50s of 1 µg/ml. CFCL showed MIC50s of 2 µg/ml. 11. Serratia marcescens Most of the agents were not so active against S. marcescens. Comparatively, CRMN was active with the MIC90 of 16 µg/ml. TFLX showed MIC90s of 32 µg/ml. The others were not active with the MIC90s of 64 µg/ml or above. TFLX and IPM showed MIC50s of 1 µg/ml, 2 µg/ml, respectively.

Original languageEnglish
Pages (from-to)1627-1657
Number of pages31
JournalThe Japanese Journal of Antibiotics
Volume48
Issue number11
DOIs
Publication statusPublished - 1995 Nov

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Comparative studies on activities of antimicrobial agents against causative organisms isolated from urinary tract infections (1992): I. Susceptibility distribution'. Together they form a unique fingerprint.

Cite this