TY - JOUR
T1 - Comparative studies on activities of antimicrobial agents against causative organisms isolated from urinary tract infections (1993)
T2 - I. Susceptibility distribution
AU - Kumamoto, Yoshiaki
AU - Hirose, Takaoki
AU - Tanaka, Noriaki
AU - Hikichi, Yoshinao
AU - Shigeta, Shiro
AU - Shiraiwa, Yasuo
AU - Kameoka, Hiroshi
AU - Yoshida, Hiroshi
AU - Tazaki, Hiroshi
AU - Iri, Hisami
AU - Uchida, Hiroshi
AU - Kobayashi, Yoshio
AU - Matsuda, Seiji
AU - Kitagawa, Ryuichi
AU - Fujime, Makoto
AU - Fujita, Kazuhiko
AU - Igari, Jun
AU - Oguri, Toyoko
AU - Kosakai, Nozomu
AU - Yamaguchi, Keizo
AU - Mochida, Chikako
AU - Furusawa, Taro
AU - Takeuchi, Yasuko
AU - Moriyama, Hiromi
AU - Shibata, Kikutaro
AU - Yonezu, Seibun
AU - Takaha, Minato
AU - Matsumiya, Kiyomi
AU - Tanaka, Michio
AU - Kaku, Mitsuo
AU - Sugawara, Kazuyuki
PY - 1995/11
Y1 - 1995/11
N2 - The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 657 bacterial strains isolated from patients with urinary tract infections in 10 hospitals during the period of June 1993 to May 1994. Of the above total bacterial isolates, Gram-positive bacteria accounted for 28.3% and a majority of them were Enterococcus faecalis. Gram-negative bacteria accounted for 71.7% and most of them were Escherichia coli. 1. Enterococcus faecalis Ampicillin (ABPC), imipenem (IPM) and vancomycin (VCM) showed the highest activities against E. faecalis isolated from patients with urinary tract infections. The MIC90s of them were 2 µg/ml. Piperacillin (PIPC) was also active with the MIC90 of 8 µg/ml. The others were not so active with the MIC90s of 32 µg/ml or above. 2. Staphylococcus aureus including MRSA VCM showed the highest activities against S. aureus isolated from patients with urinary tract infections. Its MIC90 was 1 µg/ml. Arbekacin (ABK) was also active with the MIC90 of 2 µg/ml. The others were not so active with the MIC90s of 32 µg/ml or above. 3. Staphylococcus epidermidis VCM showed the strongest activity against S. epidermidis isolated from patients with urinary tract infections. Its MIC90 was 1 µg/ml. ABK was also active with the MIC90 of 4 µg/ml. The others except ABPC were not so active with the MIC90s of 32 µg/ml or above. 4. Streptococcus agalactiae Most of the agents were active against S. agalactiae isolated from patients with urinary tract infections. Penicillins, cephems, erythromycin (EM), and clindamycin (CLDM) showed the highest activities. The MIC90s of them were 0.25 µg/ml or below. Amikacin (AMK) and minocycline (MINO) showed somewhat low activities with the MIC90s of 16 µg/ml. 5. Citrobacter freundii IPM showed the highest activities against C. freundii isolated from patients with urinary tract infections. Its MIC90 was 2 µg/ml. Cefozopran (CZOP) and gentamicin (GM) were also active with the MIC90s of 8 µg/ml. Penicillins and cephems generally were not so active. 6. Enterobacter cloacae IPM and GM showed the highest activities against E. cloacae. The MIC90s of them were 1 µg/ml. CZOP and tosufloxacin (TFLX) were also active with the MIC90s of 8 µg/ml. Penicillins and cephems except CZOP showed lower activities with the MIC90s of 64 µg/ml or above. 7. Escherichia coli Most of antimicrobial agents were active against E. coli. Flomoxef (FMOX), CZOP, IPM, CPFX and TFLX showed the highest activities against E. coli. The MIC90s of them were 0.125 µg/ml or below. Cefmenoxime (CMX), ceftazidime (CAZ), cefuzonam (CZON), latamoxef (LMOX), carumonam (CRMN), norfloxacin (NFLX) and ofloxacin (OFLX) were also active with the MIC90s of 0.25 µg/ml. Penicillins and MINO were not so active with the MIC90s of 32 µg/ml or above. 8. Klebsiella pneumoniae CZOP, IPM and CRMN showed the highest activities against K. pneumoniae. The MIC90s of them were 0.125 µg/ml or below. CAZ, CZON, CFIX, CPFX and TFLX were also active the MIC90s of 0.25 µg/ml. Penicillins were not so active with the MIC90s of 128 µg/ml or above. 9. Proteus mirabilis P. mirabilis was susceptible to a majority of drugs. CMX, CAZ, CZON, LMOX, CFIX, CRMN and CPFX showed the highest activities against P. mirabilis isolated from patients with urinary tract infections. The MIC90s of them were 0.125 µg/ml or below. MINO was not so active with the MIC90 of 256 µg/ml or above. 10. Pseudomonas aeruginosa Most of the agents were not so active against P. aeruginosa. IPM showed MIC90 of 8 µg/ml. The others were not so active with the MIC90s of 32 µg/ml or above. IPM and CPFX showed MIC50s of 1 µg/ml. TOB showed MIC50 of 2 µg/ml. 11. Serratia marcescens Most of the agents were not so active against S. marcescens. All agents showed MIC90s of 32 µg/ml or above. IPM showed MIC50 of 2 µg/ml, CRMN and GM showed MIC50s of 4 µg/ml, respectively.
AB - The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 657 bacterial strains isolated from patients with urinary tract infections in 10 hospitals during the period of June 1993 to May 1994. Of the above total bacterial isolates, Gram-positive bacteria accounted for 28.3% and a majority of them were Enterococcus faecalis. Gram-negative bacteria accounted for 71.7% and most of them were Escherichia coli. 1. Enterococcus faecalis Ampicillin (ABPC), imipenem (IPM) and vancomycin (VCM) showed the highest activities against E. faecalis isolated from patients with urinary tract infections. The MIC90s of them were 2 µg/ml. Piperacillin (PIPC) was also active with the MIC90 of 8 µg/ml. The others were not so active with the MIC90s of 32 µg/ml or above. 2. Staphylococcus aureus including MRSA VCM showed the highest activities against S. aureus isolated from patients with urinary tract infections. Its MIC90 was 1 µg/ml. Arbekacin (ABK) was also active with the MIC90 of 2 µg/ml. The others were not so active with the MIC90s of 32 µg/ml or above. 3. Staphylococcus epidermidis VCM showed the strongest activity against S. epidermidis isolated from patients with urinary tract infections. Its MIC90 was 1 µg/ml. ABK was also active with the MIC90 of 4 µg/ml. The others except ABPC were not so active with the MIC90s of 32 µg/ml or above. 4. Streptococcus agalactiae Most of the agents were active against S. agalactiae isolated from patients with urinary tract infections. Penicillins, cephems, erythromycin (EM), and clindamycin (CLDM) showed the highest activities. The MIC90s of them were 0.25 µg/ml or below. Amikacin (AMK) and minocycline (MINO) showed somewhat low activities with the MIC90s of 16 µg/ml. 5. Citrobacter freundii IPM showed the highest activities against C. freundii isolated from patients with urinary tract infections. Its MIC90 was 2 µg/ml. Cefozopran (CZOP) and gentamicin (GM) were also active with the MIC90s of 8 µg/ml. Penicillins and cephems generally were not so active. 6. Enterobacter cloacae IPM and GM showed the highest activities against E. cloacae. The MIC90s of them were 1 µg/ml. CZOP and tosufloxacin (TFLX) were also active with the MIC90s of 8 µg/ml. Penicillins and cephems except CZOP showed lower activities with the MIC90s of 64 µg/ml or above. 7. Escherichia coli Most of antimicrobial agents were active against E. coli. Flomoxef (FMOX), CZOP, IPM, CPFX and TFLX showed the highest activities against E. coli. The MIC90s of them were 0.125 µg/ml or below. Cefmenoxime (CMX), ceftazidime (CAZ), cefuzonam (CZON), latamoxef (LMOX), carumonam (CRMN), norfloxacin (NFLX) and ofloxacin (OFLX) were also active with the MIC90s of 0.25 µg/ml. Penicillins and MINO were not so active with the MIC90s of 32 µg/ml or above. 8. Klebsiella pneumoniae CZOP, IPM and CRMN showed the highest activities against K. pneumoniae. The MIC90s of them were 0.125 µg/ml or below. CAZ, CZON, CFIX, CPFX and TFLX were also active the MIC90s of 0.25 µg/ml. Penicillins were not so active with the MIC90s of 128 µg/ml or above. 9. Proteus mirabilis P. mirabilis was susceptible to a majority of drugs. CMX, CAZ, CZON, LMOX, CFIX, CRMN and CPFX showed the highest activities against P. mirabilis isolated from patients with urinary tract infections. The MIC90s of them were 0.125 µg/ml or below. MINO was not so active with the MIC90 of 256 µg/ml or above. 10. Pseudomonas aeruginosa Most of the agents were not so active against P. aeruginosa. IPM showed MIC90 of 8 µg/ml. The others were not so active with the MIC90s of 32 µg/ml or above. IPM and CPFX showed MIC50s of 1 µg/ml. TOB showed MIC50 of 2 µg/ml. 11. Serratia marcescens Most of the agents were not so active against S. marcescens. All agents showed MIC90s of 32 µg/ml or above. IPM showed MIC50 of 2 µg/ml, CRMN and GM showed MIC50s of 4 µg/ml, respectively.
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U2 - 10.11553/antibiotics1968b.48.1757
DO - 10.11553/antibiotics1968b.48.1757
M3 - Article
C2 - 8558757
AN - SCOPUS:0028824841
VL - 48
SP - 1757
EP - 1787
JO - The Japanese Journal of Antibiotics
JF - The Japanese Journal of Antibiotics
SN - 0368-2781
IS - 11
ER -