Comparative studies on activities of antimicrobial agents against causative organisms isolated from urinary tract infections (1991): I. Susceptibility distribution

Yoshiaki Kumamoto, Takaoki Hirose, Noriaki Tanaka, Yoshinao Hikichi, Shiro Shigeta, Yasuo Shiraiwa, Hiroshi Kameoka, Hiroshi Yoshida, Masahiro Ogata, Hiroshi Tazaki, Hisami Iri, Hiroshi Uchida, Yoshio Kobayashi, Seiji Matsuda, Ryuichi Kitagawa, Makoto Fujime, Kazuhiko Fujita, Jun Igari, Toyoko Oguri, Nozomu KosakaiKeizo Yamaguchi, Chikako Mochida, Taro Furusawa, Yasuko Takeuchi, Hiromi Moriyama, Kikutaro Shibata, Seibun Yonezu, Minato Takaha, Kiyomi Matsumiya, Michio Tanaka, Mitsuo Kaku, Kazuyuki Sugawara

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Abstract

The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 751 bacterial strains isolated from patients with urinary tract infections in 11 hospitals during the period of June 1991 to May 1992. Of the above total bacterial isolates, Gram-positive bacteria accounted for 28.6% and a majority of them were Enterococcus faecalis. Gram-negative bacteria accounted for 71.4% and most of them were Escherichia coli. 1. Enterococcus faecalis Ampicillin (ABPC), imipenem (IPM) and vancomycin (VCM) showed the highest activities against E. faecalis isolated from patients with urinary tract infections. The MIC90s of them were 2 µg/ml. Piperacillin (PIPC) and chloramphenicol (CP) were also active with the MIC90s of 8µg/ml. The others were not so active with the MIC90s of 32 µg/ml or above. 2. Staphylococcus aureus including MRSA Arbekacin (ABK) showed the highest activities against S. aureus isolated from patients with urinary tract infections. Its MIC90 was 0.5/µg/ml. VCM was also active with its MIC90 of 1µg/ml. The others were not so active with the MIC90s of 32µg/ml or above. 3. Citrobacter freundii Ciprofloxacin (CPFX) showed the highest activities against C. freundii isolated from patients with urinary tract infections. Its MIC90 was 0.5µg/ml. IPM, gentamicin (GM), ABK and norfloxacin (NFLX) were also active with the MIC90s of 1 µg/ml. Penicillins and cephems were not so active. 4. Enterobacter cloacae IPM showed the highest activities against E. cloacae isolated from patients with urinary tract infections. Its MIC90 was 0.5µg/ml. CPFX was also active with the MIC90 of 2µg/ml. Aminoglycosides were active comparatively. The MIC90s of them were 4µg/ml. Penicillins and cephems generally showed lower activities. 5. Escherichia coli IPM and ciprofloxacin (CPFX) showed the highest activities against E. coli isolated from patients with urinary tract infections. The MIC90s of them were 0.125µg/ml or below. Flomoxef (FMOX), cefmenoxime (CMX), cefuzonam (CZON), latamoxef (LMOX), norfloxacin (NFLX) and ofloxacin (OFLX) were also active with the MIC90s of 0.25µg/ml. Penicillins except mecillinam (MPC) were not so active showing the MIC90s of 32µg/ml or above. 6. Klebsiella pneumoniae IPM showed the highest activities against K. pneumoniae isolated from patients with urinary tract infections. Its MIC90 was 0.25µg/ml. Gentamicin (GM) and arbekacin (ABK) were also active with the MIC90s of 0.5µg/ml, respectively. But minocycline (MINO) and penicillins were not so active showing the MIC90s of 32µg/ml or above. 7. Proteus mirabilis Most of the agents were active against P. mirabilis. Cephems except CEZ were generally active with the MIC90s in a range of ≦0.125µg/ml~2µg/ml. CRMN, NFLX, OFLX and CPFX were also active with the MIC90s of 0.125µg/ml or below. Penicillins were not so active. 8. Pseudomonas aeruginosa Most of the agents were not so active against P. aeruginosa. IPM showed the MIC90 of 8 µg/ml. CAZ, CRMN and AMK showed the MIC90s of 32µg/ml. IPM and TOB showed the MIC50s of 1µg/ml, 2µg/ml, respectively. 9. Serratia marcescens Most of the agents were not so active against S. marcescens. Comparatively, IPM was active with the MIC90 of 2µg/ml. CAZ, CRMN and ABK showed the MIC90s of 16µg/ml. Penicillins and cephems except CAZ were not active showing the MIC90s of 64µg/ml or above.

Original languageEnglish
Pages (from-to)1394-1421
Number of pages28
JournalThe Japanese Journal of Antibiotics
Volume48
Issue number10
DOIs
Publication statusPublished - 1995 Oct

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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