TY - JOUR
T1 - Comparative studies on activities of antimicrobial agents against causative organisms isolated from urinary tract infections (1990)
T2 - I. Susceptibility distribution
AU - Kumamoto, Yoshiaki
AU - Hirose, Takaoki
AU - Tanaka, Noriaki
AU - Hikichi, Yoshinao
AU - Shigeta, Shiro
AU - Shiraiwa, Yasuo
AU - Kameoka, Hiroshi
AU - Yoshida, Hiroshi
AU - Ogata, Masahiro
AU - Tazaki, Hiroshi
AU - Iri, Hisami
AU - Uchida, Hiroshi
AU - Kobayashi, Yoshio
AU - Matsuda, Seiji
AU - Kitagawa, Ryuichi
AU - Fujime, Makoto
AU - Fujita, Kazuhiko
AU - Igari, Jun
AU - Oguri, Toyoko
AU - Kosakai, Nozomu
AU - Yamaguchi, Keizo
AU - Mochida, Chikako
AU - Furusawa, Taro
AU - Takeuchi, Yasuko
AU - Moriyama, Hiromi
AU - Shibata, Kikutaro
AU - Yonezu, Seibun
AU - Takaha, Minato
AU - Matsumiya, Kiyomi
AU - Tanaka, Michio
AU - Kaku, Mitsuo
AU - Sugawara, Kazuyuki
PY - 1995/10
Y1 - 1995/10
N2 - The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 848 bacterial strains isolated from patients with urinary tract infections in 10 hospitals during the period of June 1990 to May 1991, Of the above total bacterial isolates, Gram-positive bacteria accounted for 23.9% and a majority of them were Enterococcus faecalis. Gram-negative bacteria accounted for 76.1% and most of them were Escherichia coli. 1. Enterococcus faecalis Ampicillin (ABPC), imipenem (IPM) and vancomycin (VCM) showed the highest activities against E. faecalis isolated from patients with urinary tract infections. The MIC90s of them were 2 µg/ml. Piperacillin (PIPC) was also active with the MIC90 of 4µg/ml. The others were not so active with the MIC90s of 32µg/ml or above. 2. Staphylococcus aureus VCM and arbekacin (ABK) showed the highest activities against S. aureus isolated from patients with urinary tract infections. The MIC90S of them were 1µg/ml. The others were not so active with the MIC90s of 32µg/ml or above. 3. Escherichia coli Cefozopran (CZOP), carumonam (CRMN) and ofloxacin (OFLX) showed the highest activities against E. coli isolated from patients with urinary tract infections. The MIC90s of them were of 0.125µg/ml or below. IPM, cefotiam (CTM) and cefmenoxime (CMX) were also active with the MIC90s of 0.25µg/ml. Penicillins were not so active with the MIC90s of 32µg/ml or above. 4. Klebsiella pneumoniae Flomoxef (FMOX), Cefixime (CFIX), CZOP and CRMN showed the highest activities against K. pneumoniae isolated from patients with urinary tract infections. The MIC90s of them were of 0.125µg/ml or below. IPM and gentamicin (GM) were also active with the MIC90s of 0.25µg/ml and 0.5µg/ml, respectively. All other cephems were also active with the MIC90s of 4µg/ml or below. 5. Citrobacter freundii GM and IPM showed the highest activities against C. freundii isolated from patients with urinary tract infections. The MIC90s of them were 1µg/ml. Amikacin (AMK) was also active with the MIC90 of 4µg/ml. The others were not so active. 6. Enterobacter cloacae IPM and GM showed the highest activities against E. cloacae isolated from patients with urinary tract infections. The MIC90s of them MIC90s of 0.5µg/ml. AMK and OFLX were also active with the MIC90s of 4µg/ml. Penicillins and cephems generally showed lower activities. 7. Proteus mirabilis Most of the agents were active against P. mirabilis. Cephems were generally active with the MIC90S in a range of ≦0.125µg/ml-4µg/ml. CRMN, OFLX and PIPC were also active with the MIC90s in a range of ≦0.125µg/ml-0.5µg/ml. But minocycline (MINO) was not so active with the MIC90 of 64µg/ml. 8. Serratia marcescens Most of the agents were not so active against S. marcescens. Comparatively, CRMN was active with the MIC90 of 16µg/ml. Penicillins and cephems were not active with the MIC90s of over than 256µg/ml. 9. Pseudomonas aeruginosa Most of the agents were not so active against P. aeruginosa. IPM showed the MIC90 of 16µg/ml, CAZ, CZOP and aztreonam (AZT) showed the MIC90 of 32µg/ml.
AB - The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 848 bacterial strains isolated from patients with urinary tract infections in 10 hospitals during the period of June 1990 to May 1991, Of the above total bacterial isolates, Gram-positive bacteria accounted for 23.9% and a majority of them were Enterococcus faecalis. Gram-negative bacteria accounted for 76.1% and most of them were Escherichia coli. 1. Enterococcus faecalis Ampicillin (ABPC), imipenem (IPM) and vancomycin (VCM) showed the highest activities against E. faecalis isolated from patients with urinary tract infections. The MIC90s of them were 2 µg/ml. Piperacillin (PIPC) was also active with the MIC90 of 4µg/ml. The others were not so active with the MIC90s of 32µg/ml or above. 2. Staphylococcus aureus VCM and arbekacin (ABK) showed the highest activities against S. aureus isolated from patients with urinary tract infections. The MIC90S of them were 1µg/ml. The others were not so active with the MIC90s of 32µg/ml or above. 3. Escherichia coli Cefozopran (CZOP), carumonam (CRMN) and ofloxacin (OFLX) showed the highest activities against E. coli isolated from patients with urinary tract infections. The MIC90s of them were of 0.125µg/ml or below. IPM, cefotiam (CTM) and cefmenoxime (CMX) were also active with the MIC90s of 0.25µg/ml. Penicillins were not so active with the MIC90s of 32µg/ml or above. 4. Klebsiella pneumoniae Flomoxef (FMOX), Cefixime (CFIX), CZOP and CRMN showed the highest activities against K. pneumoniae isolated from patients with urinary tract infections. The MIC90s of them were of 0.125µg/ml or below. IPM and gentamicin (GM) were also active with the MIC90s of 0.25µg/ml and 0.5µg/ml, respectively. All other cephems were also active with the MIC90s of 4µg/ml or below. 5. Citrobacter freundii GM and IPM showed the highest activities against C. freundii isolated from patients with urinary tract infections. The MIC90s of them were 1µg/ml. Amikacin (AMK) was also active with the MIC90 of 4µg/ml. The others were not so active. 6. Enterobacter cloacae IPM and GM showed the highest activities against E. cloacae isolated from patients with urinary tract infections. The MIC90s of them MIC90s of 0.5µg/ml. AMK and OFLX were also active with the MIC90s of 4µg/ml. Penicillins and cephems generally showed lower activities. 7. Proteus mirabilis Most of the agents were active against P. mirabilis. Cephems were generally active with the MIC90S in a range of ≦0.125µg/ml-4µg/ml. CRMN, OFLX and PIPC were also active with the MIC90s in a range of ≦0.125µg/ml-0.5µg/ml. But minocycline (MINO) was not so active with the MIC90 of 64µg/ml. 8. Serratia marcescens Most of the agents were not so active against S. marcescens. Comparatively, CRMN was active with the MIC90 of 16µg/ml. Penicillins and cephems were not active with the MIC90s of over than 256µg/ml. 9. Pseudomonas aeruginosa Most of the agents were not so active against P. aeruginosa. IPM showed the MIC90 of 16µg/ml, CAZ, CZOP and aztreonam (AZT) showed the MIC90 of 32µg/ml.
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U2 - 10.11553/antibiotics1968b.48.1295
DO - 10.11553/antibiotics1968b.48.1295
M3 - Article
C2 - 8544337
AN - SCOPUS:0028885913
VL - 48
SP - 1295
EP - 1316
JO - The Japanese Journal of Antibiotics
JF - The Japanese Journal of Antibiotics
SN - 0368-2781
IS - 10
ER -