Comparative studies on activities of antimicrobial agents against causative organisms isolated from urinary tract infections (1990): I. Susceptibility distribution

The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 848 bacterial strains isolated from patients with urinary tract infections in 10 hospitals during the period of June 1990 to May 1991, Of the above total bacterial isolates, Gram-positive bacteria accounted for 23.9% and a majority of them were Enterococcus faecalis. Gram-negative bacteria accounted for 76.1% and most of them were Escherichia coli. 1. Enterococcus faecalis Ampicillin (ABPC), imipenem (IPM) and vancomycin (VCM) showed the highest activities against E. faecalis isolated from patients with urinary tract infections. The MIC₉₀s of them were 2 µg/ml. Piperacillin (PIPC) was also active with the MIC₉₀ of 4µg/ml. The others were not so active with the MIC₉₀s of 32µg/ml or above. 2. Staphylococcus aureus VCM and arbekacin (ABK) showed the highest activities against S. aureus isolated from patients with urinary tract infections. The MIC90S of them were 1µg/ml. The others were not so active with the MIC₉₀s of 32µg/ml or above. 3. Escherichia coli Cefozopran (CZOP), carumonam (CRMN) and ofloxacin (OFLX) showed the highest activities against E. coli isolated from patients with urinary tract infections. The MIC₉₀s of them were of 0.125µg/ml or below. IPM, cefotiam (CTM) and cefmenoxime (CMX) were also active with the MIC₉₀s of 0.25µg/ml. Penicillins were not so active with the MIC₉₀s of 32µg/ml or above. 4. Klebsiella pneumoniae Flomoxef (FMOX), Cefixime (CFIX), CZOP and CRMN showed the highest activities against K. pneumoniae isolated from patients with urinary tract infections. The MIC₉₀s of them were of 0.125µg/ml or below. IPM and gentamicin (GM) were also active with the MIC₉₀s of 0.25µg/ml and 0.5µg/ml, respectively. All other cephems were also active with the MIC₉₀s of 4µg/ml or below. 5. Citrobacter freundii GM and IPM showed the highest activities against C. freundii isolated from patients with urinary tract infections. The MIC₉₀s of them were 1µg/ml. Amikacin (AMK) was also active with the MIC₉₀ of 4µg/ml. The others were not so active. 6. Enterobacter cloacae IPM and GM showed the highest activities against E. cloacae isolated from patients with urinary tract infections. The MIC₉₀s of them MIC₉₀s of 0.5µg/ml. AMK and OFLX were also active with the MIC₉₀s of 4µg/ml. Penicillins and cephems generally showed lower activities. 7. Proteus mirabilis Most of the agents were active against P. mirabilis. Cephems were generally active with the MIC₉₀S in a range of ≦0.125µg/ml-4µg/ml. CRMN, OFLX and PIPC were also active with the MIC₉₀s in a range of ≦0.125µg/ml-0.5µg/ml. But minocycline (MINO) was not so active with the MIC₉₀ of 64µg/ml. 8. Serratia marcescens Most of the agents were not so active against S. marcescens. Comparatively, CRMN was active with the MIC₉₀ of 16µg/ml. Penicillins and cephems were not active with the MIC₉₀s of over than 256µg/ml. 9. Pseudomonas aeruginosa Most of the agents were not so active against P. aeruginosa. IPM showed the MIC₉₀ of 16µg/ml, CAZ, CZOP and aztreonam (AZT) showed the MIC₉₀ of 32µg/ml.