Comparative in vitro activity of S-4661, a new parenteral carbapenem, and other antimicrobial agents against respiratory pathogens

Akira Watanabe, Hiroshi Takahashi, Tohru Kikuchi, Takao Kobayashi, Kazunori Gomi, Shigeru Fujimura, Yutaka Tokue, Toshihiro Nukiwa

    Research output: Contribution to journalArticlepeer-review

    33 Citations (Scopus)

    Abstract

    The activity of S-4661, a new parenteral carbapenem antibiotic, was evaluated against 202 recent clinical isolates of respiratory pathogens. S-4661 was similar to or 2 times more active than imipenem, meropenem, and biapenem, and 8-128 times more active than ceftazidime against gram-positive bacteria. Against gram-negative bacteria, S-4661 was slightly less active than meropenem, but 2-8 times more active than the other agents. In particular, against Pseudomonas aeruginosa S-4661 showed the most potent activity. Th us it was found that S-4661 possesses a potent and well-balanced activity against respiratory pathogens. Copyright (C) 2000 S. Karger AG, Basel.

    Original languageEnglish
    Pages (from-to)184-187
    Number of pages4
    JournalChemotherapy
    Volume46
    Issue number3
    DOIs
    Publication statusPublished - 2000 Jan 1

    Keywords

    • Antimicrobial activity
    • Carbapenem
    • Pseudomonas aeruginosa
    • Respiratory pathogens
    • S-4661

    ASJC Scopus subject areas

    • Oncology
    • Pharmacology
    • Drug Discovery
    • Pharmacology (medical)
    • Infectious Diseases

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