Abstract
The activity of S-4661, a new parenteral carbapenem antibiotic, was evaluated against 202 recent clinical isolates of respiratory pathogens. S-4661 was similar to or 2 times more active than imipenem, meropenem, and biapenem, and 8-128 times more active than ceftazidime against gram-positive bacteria. Against gram-negative bacteria, S-4661 was slightly less active than meropenem, but 2-8 times more active than the other agents. In particular, against Pseudomonas aeruginosa S-4661 showed the most potent activity. Th us it was found that S-4661 possesses a potent and well-balanced activity against respiratory pathogens. Copyright (C) 2000 S. Karger AG, Basel.
Original language | English |
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Pages (from-to) | 184-187 |
Number of pages | 4 |
Journal | Chemotherapy |
Volume | 46 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2000 Jan 1 |
Keywords
- Antimicrobial activity
- Carbapenem
- Pseudomonas aeruginosa
- Respiratory pathogens
- S-4661
ASJC Scopus subject areas
- Oncology
- Pharmacology
- Drug Discovery
- Pharmacology (medical)
- Infectious Diseases