Comparative Genomic Hybridization defines frequent loss on 16p in human anaplastic thyroid carcinoma

Yoshifumi Komoike, Yasuhiro Tamaki, Isao Sakita, Naohiro Tomita, Masayuki Ohue, Mitsugu Sekimoto, Michihiko Miyazaki, Masao Kadota, Norikazu Masuda, Masaru Ooka, Tadashi Ohnishi, Yoshiaki Nakano, Takazumi Kozaki, Tetsuro Kobayashi, Nariaki Matsuura, Takayuki Ikeda, Akira Horii, Morito Monden

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)

Abstract

Anaplastic thyroid cancer (ATC) is one of the malignant tumors with the poor prognosis that is thought to arise from well-differentiated thyroid cancer (DTC). To investigate the molecular mechanism of ATC, we studied genomic alterations of eight ATC cell lines and three DTC cell lines by means of the comparative genomic hybridization (CGH) method. Loss of 16p was observed in five of eight ATC cell lines (62.5%), but none of the three DTC cell lines showed loss of this chromosome arm. It is notable that loss of 18q [7/8 of ATC (87.5%), 2/3 of DTC (67%)] and gain of 20q [5/8 of ATC (62.5%), 3/3 of DTC (100%)] were frequently seen in both histologic types. Our results suggest that there is a gene in 16p that is closely associated with transformation from well-differentiated thyroid cancer to anaplastic cancer.

Original languageEnglish
Pages (from-to)1157-1162
Number of pages6
JournalInternational journal of oncology
Volume14
Issue number6
DOIs
Publication statusPublished - 1999 Jun

Keywords

  • Anaplastic thyroid cancer
  • Comparative genomic hybridization
  • Genomic imbalance

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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