Comparative clinical study of 7432-S (ceftibuten) and cefaclor in chronic respiratory tract infections by A double-blind study

Masaru Nasu, Akira Saitoh, Kohtaro Ohizumi, Izumi Hayashi, Hiroyuki Kobayashi, Kohya Shiba, Shigeki Odagiri, Fumio Miki, Yoshihito Niki, Atsushi Saitoh, Akira Saitoh, Masumi Tomizawa, Ichiro Nakayama, Yohmei Hiraga, Kazuo Takebe, Katsuhiro Okamoto, Morio Sagara, Kiuoshi Konno, Kohtaro Ohizumi, Akira WatanabeSeiichi Aonuma, Tamotus Takishima, Shiroh Ida, Izumi Hayashi, Kikuo Ohnuma, Masaaki Arakawa, Kohichi Wada, Hidetsugu Higuchi, Osamu Sekine, Nobuki Aoki, Masataka Katsh, Tsuguzi Okui, Toshio Fukui, Toshito Tohgoh, Takanori Fujita, Atsushi Azisawa, Ken Kawai, Otohiko Kunii, Yasuo Ono, Hajime Nishiya, Tsukoh Ohtani, Toshiaki Haga, Syuichi Sawamoto, Yoshio Uzuka, Atsushi Saitoh, Jingoro Shimada, Kohya Shiba, Kihachiro Shimizu, Teppei Kumada, Junichi Katahira, Tomoko Fukada, Hiroyuki Kobayashi, Shin Kawai, Hiroshi Oshitani, Tatsuo Katoh, Hideo Mogami, Kaoru Shimada, Yasuyuki Sano, Yasufumi Miyamoto, Takashi Inamatsu, Makiko Fukavama, Junzaburo Kabe, Kohichiro Kudo, Hideo Ikemoto, Kazuyoshi Watanabe, Tsuneo Hamamoto, Mayumi Takahashi, Hiroichi Tanimoto, Yoshitaka Nakamori, Nadhiko Chonabayashi, Tatsuo Nakatani, Takao Ohkubo, Akira Itoh, Hirotada Ikeda, Masanori Matsumura, Masanori Ri, Takaaki Miwa, Shigeki Qdagiri, Kaneo Suzuki, Kou Murohashi, Hiroshi Takahashi, Hiroyuki Numata, Yuuji Watanuki, Kaoru Ohyama, Fumio Miki, Rinzoh Soejima, Yoshihito Niki, Yoshihisa Nakagawa, Yoshiro Sawae, Yukio Kumagai, Hozumi Yamada, Osamu Katoh, Kohei Hara, Masaki Hirota, Keizo Yamaguchi, Sigeru Kohno, Yasumasa Doutsij, Akira Yasuoka, Kazuo Sasayama, Hiroshi Yamada, Toshiaki Hayashi, Yoichi Inoue, Masafumi Hayashida, Keizoh Matsumoto, Harumi Shishido, Tsuyoshi Nagatake, Masakazu Takasugi, Yoshiaki Utsunomiya, Masaru Nasu, Hideaki Shigeno, Jun Gotoh, Takayoshi Tashiro, Atsushi Saitoh, Yoshiteru Shigeno, Tsuyoshi Ueiiara, Yuei Irabu, Mitsuyoshi Nakashima

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    2 Citations (Scopus)

    Abstract

    We conducted a comparative double-blind study of 7432-s (ceftibuten), a new oral cephem antibiotic, and cefaclor (CCL) to evaluate the efficacy, safety and usefulness of both drugs in the treatment of chronic respiratory tract infections. 7432-S was given orally at a daily dosage of 400 mg, and CCL at a daily dosage of 1500 mg for 14 days. The following results were obtained: 1) Of the total 170 patiens (85 in the 7432-S group, 85 in the CCL group), 145 were evaluated for efficacy by the committee members (71 in the 7432-S group, 74 in the CCL group). No significant differrence was noted between the two drug groups with respect to the exclusion/dropout percentage, or patient background. 2) The clinical efficacy rate judged by the committee members was 71.8% for the 7432-S group and 71.6 % for the CCL group, with no significant difference between the two drug groups. Nor was any significant difference noted between the two drug groups in the response rate as judged by the physicians. Bacteriologically, the elimination rate was 76.9% (30/39 strains) for the 7432-S group and 64.7% (22/34 strains) for the CCL group, with no significant difference between the groups. 3) As for the incidence of adverse reactions or abnormal labaratory findings, there was also no significant difference between the groups. 4) The usefulness rate judged by the committee members was 67.1% for the 7432-S group and 68.0% for the CCL group, with no significant difference between the groups. Nor was any significant difference noted in the evaluation of usefulness as judged by the physicians. These results demonstrated that 7432-S administered at a daily dosage of 400 mg (in two divided portions) was as useful as CCL at a daily dosage of 1500 mg (in three divided portions) in the treatment of chronic respiratory tract infections.

    Original languageEnglish
    Pages (from-to)619-643
    Number of pages25
    JournalChemotherapy
    Volume37
    DOIs
    Publication statusPublished - 1989

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

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  • Cite this

    Nasu, M., Saitoh, A., Ohizumi, K., Hayashi, I., Kobayashi, H., Shiba, K., Odagiri, S., Miki, F., Niki, Y., Saitoh, A., Saitoh, A., Tomizawa, M., Nakayama, I., Hiraga, Y., Takebe, K., Okamoto, K., Sagara, M., Konno, K., Ohizumi, K., ... Nakashima, M. (1989). Comparative clinical study of 7432-S (ceftibuten) and cefaclor in chronic respiratory tract infections by A double-blind study. Chemotherapy, 37, 619-643. https://doi.org/10.11250/chemotherapy1953.37.Supplement1_619