Comparative clinical study between apalcillin and carbenicillin against chronic respiratory tract infections by well-controlled study

Kenzo Shiota, Fumio Miki, Michihide Kawai, Yasumichi Kato, Akira Saito, Ichiro Nakayama, Masumi Tomizawa, Fumio Nagahama, Takehito Nakabayashi, Yuichi Kagami, Akira Watanabe, Kotaro Oizumi, Kiyoshi Konno, Hajimu Takeda, Shiro Kawashima, Osamu Sekine, Nobuki Aoki, Fusanosuke Yamasaku, Yasutoshi Suzuki, Kihachiro ShimizuToshihiro Fujii, Ryoichi Muraki, Kunio Imadaka, Hisashi Takizuka, Masato Nakano, Kenichi Okayama, Yoshichika Kanai, Shinji Okui, Masataka Katsu, Keimei Mashimo, Otohiko Kunii, Kazufuto Fukaya, Yasushi Ueda, Atushi Saito, Keiichi Nakagawa, Masaru Koyama, Kentaro Watanabe, Tatsuo Suzuki, Shinji Motojima, Junzaburo Kabe, Kaoru Shimada, Takashi Inamatsu, Hiroichi Tanimoto, Shingo Arai, Osamu Kitamoto, Hiroyuki Kobayashi, Hideo Ikemoto, Kazuyoshi Watanabe, Kohkichi Fukushima, Akira Ito, Ryuichiro Yamazaki, Makio Kurihara, Hideyuki Hasegawa, Michinori Kohno, Fuyuhiko Higashi, Shoichiro Irimajiri, Ippei Fujimori, Kaoru Oyama, Ryusaku Shimizu, Yukio Goto, Masaru Onuma, Toshiyuki Yamamoto, Saburo Kitaura, Nobuo Maekawa, Michiyasu Nakanishi, Eiichi Yamada, Hiroshi Okubo, Yuruko Okamoto, Kyoshu Go, Fumihiko Uba, Yoshihiro Ueda, Keigo Maehara, Junko Makino, Natsuo Nishizawa, Shoichi Kawamura, Takehiro Tsujimoto, Sakimori Yamaguchi, Eiro Tsubura, Michiaki Kawano, Tomohiro Kawano, Rinzo Soejima, Yoshihiko Tano, Chiaki Fujii, Takeshi Kikuchi, Yoshiro Sawae, Kohei Hara, Atsushi Saito, Masao Nakatomi, Masaru Nasu, Nobuoki Mori, Nobuhiro Horiuchi, Kinichi Izumikawa, Tsuneo Tsutsumi, Junichiro Takeshita, Rokushi Oka, Koji Yoshio, Masamoto Nakano, Akira Ikebe, Masafumi Hayashida, Hisashi Ishikawa, Hiromaro Iwasaki, Keizo Matsumoto, Hiroshi Suzuki, Yoshio Uzuka, Haruko Iwasaki

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    For the purpose of comparison of the therapeutic effects and side effects between Apalcillin (APPC) and Carbenicillin (CBPC), a comparative clinical study was carried out in 142 patients with chronic respiratory tract infections at 31 institutions in Japan. Either of APPC or CBPC was assigned to each patient at random. Administration was performed by intravenous drip infusions for a fixed period of 14 days and the daily dosage was fixed at 2g (APPC) or 4g (CBPC). A committee consisting of several physicians who had not been informed of the name of actually given drug, made a judgement on the severity, therapeutic results and presence or absence of side effects in each patient based on the detailed subjective and objective symptoms, laboratory findings and chest X-ray films. Subsequently, the key code for the drug administered to each patient was opened and a statistical analysis was carried out by a comparison between two groups (APPC group and CBPC group) with respect to background factors, clinical effectiveness, bacteriological effectiveness, degree of improvement and side effects. Out of 142 cases originally admitted to the trial, 16 cases were excluded bacause of failure to meet the initially established protocol and 126 cases (67 from APPC group and 59 from CBPC group) were used for the analysis of effectiveness while the analysis of side effects was done in 141 cases (75 from APPC group and 66 from CBPC group). It was indicated that there was no significant difference between the two groups regarding background factors except body weight, PaCO2 and ESR. Clinical effects of APPC were good in 40 cases, fair in 7 cases, poor in 19 cases and unknown in 1 case and those of CBPC were excellent in 3 cases, good in 32 cases, fair in 15 cases, poor in 7 cases and unknown in 2 cases. There was no statistically significant difference between the both groups concerning clinical effectiveness, bacteriological effectiveness and the degree of improvement. As to the incidence of side effects, no statistically significant difference was observed between the both groups.

    Original languageEnglish
    Pages (from-to)762-793
    Number of pages32
    JournalChemotherapy
    Volume26
    Issue number6
    DOIs
    Publication statusPublished - 1978

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

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