Comparative biology of cAMP-induced germinal vesicle breakdown in marine invertebrate oocytes

Ryusaku Deguchi, Noriyo Takeda, Stephen A. Stricker

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

During maturation, oocytes must undergo a process of nuclear disassembly, or "germinal vesicle breakdown" (GVBD), that is regulated by signaling pathways involving cyclic AMP (cAMP). In vertebrate and starfish oocytes, cAMP elevation typically prevents GVBD. Alternatively, increased concentrations of intra-oocytic cAMP trigger, rather than inhibit, GVBD in several groups of marine invertebrates. To integrate what is known about the stimulation of GVBD by intra-oocytic cAMP, this article reviews published data for ascidian, bivalve, brittle star, jellyfish, and nemertean oocytes. The bulk of the review concentrates on the three most intensively analyzed groups known to display cAMP-induced GVBD-nemerteans, ascidians, and jellyfish. In addition, this synopsis also presents some previously unpublished findings regarding the stimulatory effects of intra-oocytic cAMP on GVBD in jellyfish and the annelid worm Pseudopotamilla occelata. Finally, factors that may account for the currently known distribution of cAMP-induced GVBD across animal groups are discussed.

Original languageEnglish
Pages (from-to)708-725
Number of pages18
JournalMolecular reproduction and development
Volume78
Issue number10-11
DOIs
Publication statusPublished - 2011 Oct 1

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology

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