Community-acquired Chlamydia pneumoniae pneumonia in Japan: A prospective multicenter community-acquired pneumonia study

Naoyuki Miyashita, Atsushi Saito, Shigeru Kohno, Kotaro Oizumi, Keizo Yamaguchi, Akira Watanabe, Hiroshi Oda, Hiroshi Fukano, Koichiro Yoshida, Yoshihito Niki, Toshiharu Matsushima

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    Objective. To investigate the clinical features of Chlamydia pneumoniae pneumonia in Japan and to evaluate the newly created Japanese community-acquired pneumonia (CAP) guidelines. Patients and Methods. A multicenter CAP surveillance study was carried out in 20 hospitals between December 1999 and March 2000. The diagnosis of C. pneumoniae infection was based on isolation in cell culture, the polymerase chain reaction and serologic testing of antibodies by the microimmunofluorescence test. Results. Among 232 CAP cases, C. pneumoniae was identified as the etiologic agent in 15 cases (6.5 %). C. pneumoniae was the only pathogen identified in nine of these cases, while one or more additional etiological agents were found in the other six cases. Of the present and previously reported single agent C. pneumoniae pneumonia cases, about 50% were more than 60 years old and had underlying diseases. A relatively slow pulse rate in relation to fever was not seen in these patients. The mean WBC count of all patients was normal. No patient required respiratory support or admission to an intensive care unit and no deaths occurred among these patients. Conclusion. The clinical pictures of C pneumoniae pneumonia as a single agent were mild to moderate and were remarkably different from those of cases of C. pneumoniae pneumonia concomitant with other bacteria. If the patient is less than 60 years old and some guideline headings are excluded, we think it would be possible to distinguish between C. pneumoniae and bacterial pneumonia.

    Original languageEnglish
    Pages (from-to)943-949
    Number of pages7
    JournalInternal Medicine
    Volume41
    Issue number11
    DOIs
    Publication statusPublished - 2002 Nov 1

    Keywords

    • Atypical pneumonia
    • Bacterial pneumonia
    • CAP guideline
    • Clinical feature
    • Concomitant infection

    ASJC Scopus subject areas

    • Internal Medicine

    Fingerprint Dive into the research topics of 'Community-acquired Chlamydia pneumoniae pneumonia in Japan: A prospective multicenter community-acquired pneumonia study'. Together they form a unique fingerprint.

  • Cite this

    Miyashita, N., Saito, A., Kohno, S., Oizumi, K., Yamaguchi, K., Watanabe, A., Oda, H., Fukano, H., Yoshida, K., Niki, Y., & Matsushima, T. (2002). Community-acquired Chlamydia pneumoniae pneumonia in Japan: A prospective multicenter community-acquired pneumonia study. Internal Medicine, 41(11), 943-949. https://doi.org/10.2169/internalmedicine.41.943