Combined therapy with peritoneal dialysis and hemodialysis: A multicenter retrospective observational cohort study in Japan

Yukio Maruyama, Keitaro Yokoyama, Masaaki Nakayama, Chieko Higuchi, Tsutomu Sanaka, Yoshihide Tanaka, Ken Sakai, Sonoo Mizuiri, Yasushi Otsuka, Satoru Kuriyama, Teruhiko Maeba, Hideaki Iwasawa, Toshiyuki Nakao, Tatsuo Hosoya

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Background/Aims: Combining peritoneal dialysis (PD) and hemodialysis (HD) has been common treatment option in Japan. Methods: In this retrospective, multicenter, observational study, the clinical characteristics and outcomes of 104 patients (57 ± 11 years, males 72%) who had switched from PD alone to combined therapy with PD and HD were studied. Clinical parameters were measured at baseline and after 3 months of combined therapy. Results: At baseline, urine volume, dialysate-to-plasma ratio of creatinine (D/P Cr), and total Kt/V were 150 ml/day (range: 0-2,000 ml/day), 0.67 ± 0.11, and 1.8 ± 0.4, respectively. During the first 3 months of combined therapy, body weight, urine volume, serum creatinine level, and D/P Cr decreased, whereas hemoglobin levels increased. Conclusions: In patients where PD does not result in acceptable outcomes, combined therapy with PD and HD may have potential benefits in terms of dialysis adequacy and hydration status.

Original languageEnglish
Pages (from-to)149-153
Number of pages5
JournalBlood Purification
Volume38
Issue number2
DOIs
Publication statusPublished - 2014 May 22

Keywords

  • Dialysate-to-plasma ratio of creatinine (D/P Cr)
  • Dialysis adequacy
  • Hemodialysis
  • Peritoneal dialysis
  • Peritoneal equilibration test (PET)
  • Residual renal function
  • β2 microglobulin

ASJC Scopus subject areas

  • Hematology
  • Nephrology

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