Combined therapy with hypothermia and anticytokine agents in influenza A encephalopathy

Mitsutoshi Munakata, Rie Kato, Hiroyuki Yokoyama, Kazuhiro Haginoya, Yoshiko Tanaka, Jun Kayaba, Taku Kato, Reiko Takayanagi, Hiroko Endo, Ryuiti Hasegawa, Yutaka Ejima, Kunihiko Hoshi, Kazuie Iinuma

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

Two children with influenza A-related encephalopathy were treated with a combination of mild hypothermia (deep body temperature of the forehead: 35°C) and anticytokine agents (high-dose methylprednisolone and ulinastatin), while receiving amantadine. One of the cases exhibited acute necrotizing encephalopathy on computed tomography (CT). Although no severe complications occurred, correctable hypokalemia and hyperglycemia occurred in both cases. Both patients recovered without any neurological sequelae. Our therapeutic protocol appears to be effective for managing influenza A-related encephalopathy. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)373-377
Number of pages5
JournalBrain and Development
Volume22
Issue number6
DOIs
Publication statusPublished - 2000 Oct 30

Keywords

  • Corticosteroid
  • Hypothermia
  • Influenza A virus
  • Ulinastatin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

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