Combined therapy after superselective arterial cisplatin infusion to treat maxillary squamous cell carcinoma

Kiyoto Shiga, Junkichi Yokoyama, Sho Hashimoto, Shigeru Saijo, Masaru Tateda, Takenori Ogawa, Mika Watanabe, Toshimitsu Kobayashi

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Objective: We sought to assess the efficacy of combined therapy after superselective arterial cisplatin infusion (SACI) therapy to treat the maxillary squamous cell carcinoma. Study Design: We conducted a retrospective chart review of 50 patients. After completion of two courses of SACI, 25 of the patients were successively treated by concurrent SACI and radiotherapy (AR), while the other 25 patients were treated by surgery with postoperative radiotherapy (ASR). Results: Patients with surgery (ASR) had an 88% local control rate with 75% disease-free survival rate at 60 months by Kaplan-Meier analysis, compared with 62% disease-free survival rate for patients with AR treatment. A particularly good outcome was obtained in T4 cases of the ASR group (n = 8) whose 5-year survival rate was 87% and local control rate was 100%. Conclusion/Significance: Combined SACI therapy is very effective for the treatment of maxillary squamous cell carcinomas and contributes to the improving prognoses of patients and organ preservation rates.

Original languageEnglish
Pages (from-to)1003-1009
Number of pages7
JournalOtolaryngology - Head and Neck Surgery
Volume136
Issue number6
DOIs
Publication statusPublished - 2007 Jun 1

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Combined therapy after superselective arterial cisplatin infusion to treat maxillary squamous cell carcinoma'. Together they form a unique fingerprint.

  • Cite this