Combined evaluation of plasma B-type natriuretic peptide and urinary liver-type fatty acid-binding protein/creatinine ratio is related to worsening renal function in patients undergoing elective percutaneous coronary intervention

Fumiki Yoshihara, Hiroshi Hosoda, Takahito Doi, Morikatsu Yoshida, Kazuo Kitamura, Haruko Yamamoto, Yasuhide Asaumi, Hatsue Ishibashi-Ueda, Masatsugu Kishida, Tetsuya Arisato, Miki Matsuo, Mikiya Miyazato, Satoshi Yasuda

Research output: Contribution to journalArticlepeer-review

Abstract

Background: There are few reports on the significance for the combined evaluation of blood humoral factors and urinary biomarkers in terms of worsening renal function (WRF) after coronary angiography (CAG)/percutaneous coronary arterial intervention (PCI). Method and results: Urinary liver type-fatty acid-binding protein (L-FABP), neutrophil gelatinase associated lipocalin (NGAL), and adrenomedullin (AM) were measured less than 24 h before and 3 h, 6 h, 1 day, and 2 days after CAG/PCI. WRF was defined as a > 20% decrease in the estimated GFR. WRF occurred in seven of 100 patients and the increase in L-FABP/creatinine (Cr) at 1 day after CAG/PCI was significantly higher in the WRF group than in the non-WRF group. Plasma B-type natriuretic peptide (BNP) before CAG/PCI and L-FABP/Cr at 1 day after CAG/PCI were independent predictors for WRF. The areas under the receiver-operating characteristic curves were as follows: 0.760 for BNP before CAG/PCI, 0.731 for L-FABP/Cr at 1 day after CAG/PCI, and 0.892 for BNP and L-FABP/Cr. Urinary AM levels after PCI/CAG were negatively correlated only to serum potassium levels. Gene expressions of AM and AM-receptor were detectable in renal tubule epithelial cells. AM increased intracellular second messenger levels in a dose-dependent manner. Conclusions: Our results suggest that combined evaluation of plasma BNP and urinary L-FABP/Cr is useful as a predictor of renal dysfunction in CAG/PCI patients.

Original languageEnglish
JournalClinical and experimental nephrology
DOIs
Publication statusAccepted/In press - 2021
Externally publishedYes

Keywords

  • Adrenomedullin
  • B-type natriuretic peptide
  • Liver type-fatty acid-binding protein
  • Percutaneous coronary arterial intervention
  • Worsening renal function

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

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