Combined brønsted-base-mediated direct C-H carboxylation of heteroarenes with CO2

Masanori Shigeno, Keita Sasaki, Kazuya Hanasaka, Itsuki Tohara, Kanako Nozawa-Kumada, Yoshinori Kondo

Research output: Contribution to journalReview articlepeer-review

Abstract

This review article summarizes that the combined Brønsted-base system comprising LiO-t-Bu, CsF, and 18-crown-6 efficiently proceeds the direct carboxylation of electron-rich heteroarenes, such as benzothiophene and benzofuran, with CO2. Good functional group compatibility is displayed, allowing the use of Me, MeO, halogen, CN, ketone, and amide moieties. 3-Substituted indoles are also used for C-2 carboxylation, while double-carboxylation of 2-alkylheteroarenes is achieved by LiO-t-Bu and CsF.

Original languageEnglish
JournalHeterocycles
Volume103
Issue number2
DOIs
Publication statusPublished - 2021

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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