Combinatorial synthesis of RGD model cyclic peptides utilizing a palladium-catalyzed carbonylative macrolactamization on a polymer support

Seiji Kamioka, Sayaka Shimazu, Takayuki Doi, Takashi Takahashi

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

A combinatorial synthesis of 24-member RGD models was accomplished on polymer-support. Ortho-, meta-, and para-iodobenzylamines loaded on an aldehyde linker by reductive animation were coupled with RGD sequences and various ω-amino acids by a split-and-pool method. Palladium-catalyzed carbonylative macrolactamization of the polymer-supported cyclization precursors, followed by acid cleavage, provided conformationally restricted RGD model cyclic peptides.

Original languageEnglish
Pages (from-to)681-690
Number of pages10
JournalJournal of Combinatorial Chemistry
Volume10
Issue number5
DOIs
Publication statusPublished - 2008 Sep 1

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Combinatorial synthesis of RGD model cyclic peptides utilizing a palladium-catalyzed carbonylative macrolactamization on a polymer support'. Together they form a unique fingerprint.

Cite this