Combinatorial library synthesis of two- and three-ring benzenoid amides on solid support

Akira Mori, Issei Akahoshi, Masashi Hashimoto, Takayuki Doi, Takashi Takahashi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A liquid crystalline library of 100 molecules with three benzene rings and 18 molecules with two benzene rings was synthesized on solid support by means of benzoylation or acylation and palladium(0)-catalyzed carbonylation of a secondary amine obtained by a reductive amination of 4-iodoaniline and a backbone amide linker. The conversion and purity of the final products are high enough to investigate the mesomorphic properties.

Original languageEnglish
Pages (from-to)813-815
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number4
DOIs
Publication statusPublished - 2004 Jan 19

Keywords

  • Benzenoid liquid crystals
  • Pd-catalyzed carbonylation
  • Solid-phase synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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