Combinatorial chemistry in organic synthesis

Takashi Takahashi, Takayuki Doi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Combinatorial chemistry is among the most recent topics in synthetic organic chemistry. A key feature is diversification in the development of organic reactions and in the synthesis of organic compounds. A crucial chemistry is solid-phase synthesis, which is a powerful method in order to optimize reaction conditions, to investigate scope and limitations of new reactions, and to synthesize a variety of compound libraries. Solid-supports, linkers, and strategies for the combinatorial chemistry are described. Synthetic methods (parallel synthesis and mix-and-split synthesis), analysis, and purification in the solid-phase synthesis are also described.

Original languageEnglish
Pages (from-to)426-433
Number of pages8
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume60
Issue number5
DOIs
Publication statusPublished - 2002 May

Keywords

  • Analysis
  • Combinatorial chemistry
  • High speed synthesis
  • Library
  • Linker
  • Purification
  • Solid-phase synthesis
  • Solid-support

ASJC Scopus subject areas

  • Organic Chemistry

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