Combination Therapy with Miconazole and Flucytosine for Deep-Seated Mycoses

Shigeru Kohno, Shigefumi Maesaki, Hiroshi Kakeya, Yoshihiro Yamamoto, Tetsuhiro Noda, Eisuke Sasaki, Sadanori Kawamoto, Sumio Kawamura, Takakazu Otsubo, Takashige Miyazaki, Kazunori Tomono, Mitsuo Kaku, Hironobu Koga, Takayoshi Tashiro, Kohei Hara

Research output: Contribution to journalArticle

Abstract

This study evaluated combination therapy with miconazole and flucytosine for treating deep seated mycosis. Both mycological and clinical efficacy against candidemia and pulmonary cryptococcosis were satisfactory: All four isolated Candida spp. were eradicated and all four patients with candidemia were cured, while six of nine patients with pulmonary cryptococcosis exhibited clinical improvement. The efficacy of combination therapy appeared to be low against aspergillosis, since only one of two patients with invasive pulmonary aspergillosis and two of five patients with pulmonary aspergilloma exhibited clinical improvement. Nevertheless, the clinical efficacy against aspergillosis was higher than that obtained with monotherapy in our previous study. Adverse reactions were observed in 36% (13 of 36) and abnormal laboratory findings in 22% (8 of 36) of patients treated with combination therapy; these rates were higher than those reported for monotherapy. These increases were not due to changes in serum concentrations of the two drugs due to simultaneous administration. The findings of this study suggest that combination therapy with miconazole and flucytosine may be an alternative therapy for refractory mycoses for carefully chosen patients.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalTopics in Catalysis
Volume1
Issue number2
DOIs
Publication statusPublished - 1995 Jan 1
Externally publishedYes

Keywords

  • aspergillosis
  • candidiasis
  • combination therapy
  • cryptococcosis
  • flucytosine
  • miconazole

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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  • Cite this

    Kohno, S., Maesaki, S., Kakeya, H., Yamamoto, Y., Noda, T., Sasaki, E., Kawamoto, S., Kawamura, S., Otsubo, T., Miyazaki, T., Tomono, K., Kaku, M., Koga, H., Tashiro, T., & Hara, K. (1995). Combination Therapy with Miconazole and Flucytosine for Deep-Seated Mycoses. Topics in Catalysis, 1(2), 127-132. https://doi.org/10.1007/BF02348757