Combination Therapy of Pembrolizumab plus Axitinib for a Patient on Hemodialysis with Metastatic Renal Cell Carcinoma: A Case Report

Yuki Katsumata, Yoshihide Kawasaki, Kayu Tanaka, Daisuke Nakayama, Hiromichi Katayama, Shuichi Shimada, Yohei Satake, Takuma Sato, Naoki Kawamorita, Shinichi Yamashita, Testuya Sato, Kosuke Shoji, Koji Mitsuzuka, Akihiro Ito

Research output: Contribution to journalReview articlepeer-review

Abstract

Here, we discuss the safety and management of adverse events associated with pembrolizumab plus axitinib combination therapy for metastatic renal cell carcinoma in patients on hemodialysis. A 76-year-old man was diagnosed with cT3aN0M0 renal cell carcinoma due to gross hematuria. Stereoscopic radiotherapy for metastatic lesions of the ipsilateral kidney was performed 9 years after right laparoscopic radical nephrectomy. Soon after, the patient started to receive hemodialysis due to end-stage renal disease. Further stereoscopic radiotherapy was needed for metastasis of the ipsilateral kidney and lung. Fifteen years after diagnosis, systemic therapy was necessary to control new metastases, such as in the right scapular bone. We selected pembrolizumab plus axitinib combination therapy as the first-line systemic therapy for any risk as defined by the International Metastatic RCC Database Consortium. Although we needed to pay attention to the adverse events unique to hemodialysis, he underwent this combination therapy without any difficulty for 6 months. Here, we report the practice of combination therapy in patients on hemodialysis in light of the literature.

Original languageEnglish
Pages (from-to)1522-1529
Number of pages8
JournalCase Reports in Oncology
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • Axitinib
  • Hemodialysis
  • Pembrolizumab
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Oncology

Fingerprint

Dive into the research topics of 'Combination Therapy of Pembrolizumab plus Axitinib for a Patient on Hemodialysis with Metastatic Renal Cell Carcinoma: A Case Report'. Together they form a unique fingerprint.

Cite this